INTRODUCTION Serum cystatin C can improve glomerular filtration rate (GFR) estimation over creatinine alone, but whether this translates into clinically relevant improvements in drug dosing is unclear. METHODS This prospective cohort study enrolled adults receiving scheduled intravenous vancomycin while hospitalized at the Mayo Clinic in 2012. Vancomycin dosing was based on weight, serum crea...

BACKGROUND Voriconazole concentrations display a large variability, which cannot completely be explained by known factors. We investigated the relationships of voriconazole concentration with patient-specific variables and concomitant medication to identify clinical factors affecting voriconazole clearance. METHODS A retrospective chart review of voriconazole trough concentration, laboratory ...

Focussing on the major cities of Brisbane, Sydney, and Melbourne in southeast Australia, this study seeks to determine environmental factors that distinguish between heavy rainfall events (HREs) extreme (EREs). Using daily rain gauge observations, HREs EREs are defined for each domain based, respectively, 95th 99th percentiles wet-day period 1979–2018. K-means clustering is applied mean sea-lev...

An objective method was developed to analyze longwave and shortwave trough lines in wind field data using different methods, given that these trough lines were researched in different ways. Longwave trough lines were analyzed by locating the cyclonic center and filtering candidate trough points simultaneously; the candidate longwave trough points were then traced based on distance and angle con...

Abstract A k- means clustering method is applied to daily ERA5 500-hPa heights, sea level pressure, and 850-hPa winds, 1979–2008, identify characteristic weather types (WTs) for September–November the northeast United States. The resulting WTs are analyzed in terms of structure, frequency occurrence, typical progressions, precipitation temperature characteristics, relation teleconnections. used...

In the present work the efficiency of a solar parabolic trough has been investigated experimentality. parabolic trough solar collector constitute a proven source of thermal energy for industrial process heat and power genaration. The impact of  using the partially porous media in the absorber on the efficiency of PTC (parabolic trough collector) has been investigated. The porosity of copper foa...

Background & Aims: Hypertension, hyperuricaemia and nephrotoxicity are some common side-effects of Cyclosporine A (CsA) treatment in renal transplant recipients. Previous studies suggest that Calcium Channel Blockers (CCB) can increase serum level of CsA and may improve graft function in patients receiving CsA. The aim of this study was to evaluate the effects of Diltiazem and Amlodipine on cyc...

Continued increases in Johne’s disease around the world suggest more information is needed to understand the mechanisms by which the causative agent, Mycobacterium avium subsp paratuberculosis (MAP), is spread among livestock on the farm site. Livestock watering troughs are frequented by all animals on a farm; they provide a moist, nutrient-rich environment for bacterial survival, and the troug...