نتایج جستجو برای: trophoblasts

تعداد نتایج: 1197  

2017
Xiao-Hui Wang Wei Liu Deng-Xuan Fan Wen-Ting Hu Ming-Qing Li Xiao-Yong Zhu Li-Ping Jin

Interleukin-33 (IL-33) promotes migration of cancer cells through downregulating the expression of E-cadherin. Previous studies have demonstrated that IL‑33 stimulates the proliferation of trophoblasts. However, the effect of IL‑33 on the adhesion and invasion of trophoblasts has not been investigated in detail. In the present study, the expression of IL‑33 and its receptor, IL‑1 receptor‑like ...

Journal: :Hypertension 2008
Lydia Hering Florian Herse Stefan Verlohren Joon-Keun Park Maren Wellner Fatimunnisa Qadri Robert Pijnenborg Anne C Staff Berthold Huppertz Dominik N Muller Friedrich C Luft Ralf Dechend

Maternal spiral artery remodeling is the consequence of controlled trophoblast invasive interaction with the maternal cellular environment and is fundamentally important for successful placentation. In preeclampsia, trophoblast invasion is shallow, remodeling is incomplete, and vessels develop an inflammatory appearance, termed "acute atherosis." We noted that, in our preeclampsia, human renin-...

Journal: :Blood 2003
R Tedjo Sasmono Delvac Oceandy Jeffrey W Pollard Wei Tong Paul Pavli Brandon J Wainwright Michael C Ostrowski S Roy Himes David A Hume

The c-fms gene encodes the receptor for macrophage colony-stimulating factor (CSF-1). The gene is expressed selectively in the macrophage and trophoblast cell lineages. Previous studies have indicated that sequences in intron 2 control transcript elongation in tissue-specific and regulated expression of c-fms. In humans, an alternative promoter was implicated in expression of the gene in tropho...

2015
Jennifer A. Tolen Penelope Duerksen-Hughes Kathleen Lau Philip J. Chan

Objectives. Human papillomaviruses (HPV) are associated with cell cycle arrest. This study focused on antioxidant selenomethionine (SeMet) inhibition of HPV-mediated necrosis. The objectives were to determine HPV-18 effects on embryonic cells and to evaluate SeMet in blocking HPV-18 effects. Methods. Fertilized mouse embryos were cultured for 5 days to implanted trophoblasts and exposed to eith...

Journal: :Human reproduction 2007
Mei-Rong Du Wen-Hui Zhou Feng-Ting Yan Xiao-Yong Zhu Yin-Yan He Jin-Ying Yang Da-Jin Li

BACKGROUND Cyclosporin A (CsA) is a powerful immunosuppressive that has been widely used to prevent organ rejection and to treat certain autoimmune diseases. Our previous study showed that CsA at low concentrations could promote proliferation and invasion, and inhibit apoptosis, of human first trimester trophoblasts. In the present study, we further explored the potential mechanism and signal p...

2018
Yu Ma Ling-Ran Kong Qian Ge Yuan-Yuan Lu Mo-Na Hong Yu Zhang Cheng-Chao Ruan Ping-Jin Gao

Pre-eclampsia (PE) is a life-threatening multisystem disorder leading to maternal and neonatal mortality and morbidity. Emerging evidence showed that activation of the complement system is implicated in the pathological processes of PE. However, little is known about the detailed cellular and molecular mechanism of complement activation in the development of PE. In this study, we reported that ...

Journal: :Molecular human reproduction 2001
S Matsubara I Sato

We examined the subcellular localizations of NAD(P)H oxidase, a reactive oxygen species (ROS)-producing enzyme, in fetal membrane chorion laeve trophoblasts from preterm or term pregnant women with or without chorioamnionitis (CAM). Ultrastructural enzyme histochemistry for NAD(P)H oxidase was used. In fetal membranes without CAM, approximately one quarter of the chorion laeve trophoblasts (25....

Journal: :Human reproduction 2004
H Konishi M Nakatsuka C Chekir S Noguchi Y Kamada A Sasaki Y Hiramatsu

BACKGROUND We studied the effects of advanced glycation end products (AGEs), which are known to accumulate in patients with diabetes, autoimmune diseases, or that smoke, on human trophoblasts. METHODS First trimester human chorionic villi of 6-10 week gestation were obtained. Expression and localization of the receptor for AGEs (RAGE) was examined by western blotting and immunohistochemistry....

Journal: :The Journal of Experimental Medicine 2004
Peter Parham

In placental mammals, viviparity--the production of living young within the mother's body--evolved under the auspices of the immune system. Elements of immunity were incorporated, giving pregnancy a mildly inflammatory character. Formation of the placenta, the organ that feeds the fetus, involves a cooperation between maternal natural killer (NK) cells and fetal trophoblast cells that remodels ...

2014
Rui Zhu Qiang Fu Da-Jin Li Chan Sun Li-Ping Jin Yu Tao Yan-Hong Li Di Zhang Mei-Rong Du Pei-Fen Guo Hai-Lan Piao Song-Cun Wang

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