نتایج جستجو برای: trmm 3b42rt v7
تعداد نتایج: 2075 فیلتر نتایج به سال:
PURPOSE Mechanisms mediating androgen receptor (AR) reactivation in prostate cancer that progresses after castration (castration-resistant prostate cancer; CRPC) and subsequent treatment with abiraterone (CYP17A1 inhibitor that further suppresses androgen synthesis) remain unclear. EXPERIMENTAL DESIGN Prostate cancer xenografts were examined to identify mechanism of progression after castrati...
BACKGROUND The androgen-receptor isoform encoded by splice variant 7 lacks the ligand-binding domain, which is the target of enzalutamide and abiraterone, but remains constitutively active as a transcription factor. We hypothesized that detection of androgen-receptor splice variant 7 messenger RNA (AR-V7) in circulating tumor cells from men with advanced prostate cancer would be associated with...
Prostate cancer cells demonstrate a remarkable "addiction" to androgen receptor (AR) signaling in all stages of disease progression. As such, suppression of AR signaling remains the therapeutic goal in systemic treatment of prostate cancer. A number of molecular alterations arise in patients treated with AR-directed therapies. These molecular alterations may indicate the emergence of treatment ...
The global precipitation measurement mission (GPM) has been in operation for seven years and continues to provide a vast quantity of data at finer temporospatial resolutions with improved accuracy coverage. GPM’s signature algorithm, the integrated multisatellite retrievals GPM (IMERG) is next-generation product expected wide variety research operational applications. This study evaluates lates...
Precipitation data are important for the fields of hydrology and meteorology, and are fundamental for ecosystem monitoring and climate change research. Satellite-based precipitation products are already able to provide high temporal resolution precipitation information at a global level. However, the coarse spatial resolution has restricted their use in regional level studies. In this study, mo...
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Suppression of androgen production and function provides palliation but not cure in men with prostate cancer (PCa). Therapeutic failure and progression to hormone-refractory PCa (HRPC) are often accompanied by molecular alterations involving the androgen receptor (AR). In this study, we report novel forms of AR alteration that are prevalent in HRPC. Through in silico sequence analysis and subse...
A major current challenge in the treatment of advanced prostate cancer, which can be initially controlled by medical or surgical castration, is the development of effective, safe, and affordable therapies against progression of the disease to the stage of castration resistance. Here, we showed that in LNCaP and 22Rv1 prostate cancer cells transiently overexpressing androgen receptor splice vari...
Precise spatio-temporal measurements of rainfall during seasonal monsoons are critical for accurate hydrologic analyses in the tropical regions of Southeast Asia. The use of satellite precipitation data is technologically sound but requires downscaling to minimize inherent uncertainties. The uncertainties at a local climate regime that are essential to be resolved are rarely reported; consequen...
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