With the aim of obtaining information about drug-drug interaction (DDI) between acetaminophen and some of antidepressant drugs (fluoxetine, sertraline and nortriptyline), in the present work we studied the electrochemical oxidation of acetaminophen (paracetamol) in the presence of these drugs by means of cyclic voltammetry and Controlled-potential coulometry. The reaction between N-acetyl-p-ben...

Telepresence robots will provide significant value to childhood education. They will offer children opportunities to join remote classrooms and to communicate with speakers of different languages in more enriched ways than are available by conventional video conferencing. However, the introduction of child-operated telepresence robots has yet to be tested. The design of the operation interface ...

This paper explicitly report on computer aided assembly animation of a tricycle for paraplegics who have difficulty in the use of lower limbs for mobility or driving.The development started with studying of existing tricycle and a case study of the recommended design standard for the features of vehicular cabs was taken. Analysis of the design requirements was made to determine all that would b...

Two lines of evidence point to the relationship between bipolar mood disorder and treatment-resistant depression. First, the frequency of suboptimal response to antidepressant drugs is significantly higher in bipolar than in unipolar mood disorder. Secondly, the first and the second generation mood stabilizing drugs are efficacious for augmentation of antidepressants in treatmentresistant depre...

BACKGROUND hip fractures are usually caused by a combination of reduced bone mineral density and falls; using antidepressant drugs may affect both of these. OBJECTIVE we aimed to examine associations between exposure to antidepressant drugs and the risk of hip fracture among older people, and, provided associations found, to estimate the attributable risk of hip fracture. DESIGN we conducte...

The neurotransmitter serotonin (5-hdroxytryptamine; 5-HT) has been implicated in the pathophysiology and treatment of major depression since the serendipitous discovery of antidepressant drugs in the 1950s. However, despite the generalised use of serotonin-enhancing drugs, such as the selective serotonin reuptake inhibitors (SSRIs) and the dual serotonin and norepinephrine reuptake inhibitors (...

BACKGROUND Antidepressant prescribing has been increasing in England. Studies in other countries suggest that while this may be associated with reduced suicide rates, it may also be associated with increased fatal poisoning from antidepressant drugs. We therefore conducted an ecological study to assess the association between prescription rates for antidepressants and suicide or fatal antidepre...

BACKGROUND Antidepressant drugs are among the most widely prescribed drugs in the United States; however, little is known about their use among major ethnic minority groups. METHOD Collaborative Psychiatric Epidemiology Surveys (CPES) data were analyzed to calculate nationally representative estimates of Latino and non-Latino White adults antidepressant use. SETTING The 48 coterminous Unite...

Antidepressant drugs such as the serotonin (5-HT)/norepinephrine (NE) and dopamine (DA) reuptake inhibitors activate monoaminergic neurotransmission in various brain regions, such as the amygdala, the frontal cortex or the hippocampus. Although this property is well established, the post-synaptic mechanisms by which these pharmacological agents exert therapeutic activity in major depressive dis...

Background and purpose Many drugs can worsen myasthenia symptoms. The clinician usually relies on cautionary lists compiled according to case reports. We intended provide a quantitative basis for risk comparison within the groups of antiepileptic, antidepressant, neuroleptic, sedative drugs. Methods extracted adverse drug reaction (ADR) counts (total related) from these calculated reporting odd...