Introduction: Bombesin (BN), a 14-amino acid neuropeptide, shows high affinity for the human GRP (gastrin releasing peptide) receptors, which are overexpressed by a variety of cancers, including prostate, breast, pancreas, gastrointestinal, and small cell lung cancer. Aim was to prepare [6-hydrazinopyridine-3-carboxylic acid (HYNIC0), D-Tyr6, D...

BACKGROUND Human plasma ATP concentration is reported in many studies as roughly 1000 nmol/L. The present study tested the hypothesis that the measured plasma ATP concentration is lower if ATP release from formed blood elements is inhibited during blood sample processing. A second hypothesis was that pretreatment with aspirin to inhibit platelets would reduce the measured plasma concentration o...

Bacteria-derived antimicrobial peptides known as peptidic bacteriocins offer a promising alternative to traditional antibiotics in the face of emergence multidrug-resistant bacteria. Here, nucleotide sequence gene encoding Lactococcus lactis-derived bacteriocin designated lactiscin selectively identified from GenBank® database was synthesized with an added 6⋅His and cloned into Escherichia coli...

This study sought to evaluate the impact of multiple negative charges on blood clearance kinetics and biodistribution properties of (99m)Tc-labeled RGD peptide dimers. Bioconjugates HYNIC-P6G-RGD2 and HYNIC-P6D-RGD2 were prepared by reacting P6G-RGD2 and P6D-RGD2, respectively, with excess HYNIC-OSu in the presence of diisopropylethylamine. Their IC50 values were determined to be 31 ± 5 and 41 ...

A biocontrol Bacillus velezensis strain, NT35, was isolated from the rhizosphere soil of ginseng, and its sterile filtrate obtained through a 0.22 μm filter which had significant inhibitory effect against Ilyonectria robusta, causes rusty root rot in Panax ginseng. In order to obtain best filtrate, medium fermentation conditions strain NT35 were optimized using response surface methodology (RSM...

imaging of infection and inflammation is an important issue in nuclear medicine as it may have relevant implication for the management of patients with infections or inflammatory diseases. in this regard the synthesis of human polyclonal immunoglobuline g (igg) radiolabeled with technetium-99m (99mtc) by a novel method, via a nicotinamide hydrazine derivative, was performed. the biological beha...