To determine a role of human -Defensin-2 (HBD-2) in defense against cutaneous dermatophyte infection, we investigated the induction of HBD-2 mRNA expression by a nontumorigenic human keratinocyte-derived cell line, HaCaT cells, after co-culture with microconidia collected from the colonies of Trichophyton rubrum. Co-culture of T. rubrum or Candida albicans with HaCaT cells significantly induced...

OBJECTIVE To investigate the use of 405 nm light for inhibiting the growth of selected species of dermatophytic and saprophytic fungi. BACKGROUND DATA The increasing incidence and resilience of dermatophytic fungal infections is a major issue, and alternative treatment methods are being sought. METHODS The sensitivity of the dermatophytic fungi Trichophyton rubrum and Trichophyton mentagrop...

Background: Tinea corporis is a superficial fungal infection of the glabrous skin of the trunk and extremities caused by closely related organisms of the three genera – Trichophyton, Microsporum, and Epidermophyton, collectively known as dermatophytes. The prevalence of the different species varies according to geographic and climatic regions. Trichophyton rubrum has been reported from various ...