-Catenin and T cell factor (Tcf) are distal components of the highly conserved Wnt pathway that govern cell fate and proliferation in lower organisms. Thus, we hypothesized that the regulation of -catenin and Tcf played a critical role in vascular remodeling. The first objective was to define -catenin expression in vascular smooth muscle cells (VSMCs) after balloon injury. Indeed, -catenin mRNA...

We synthesised views and experiences of three teams (student mentees, alumni mentors, staff) in our pilot mentorship scheme within a distance learning MSc, evaluated the scheme, developed conceptual model “triadic partnerships.” Thematic analysis qualitative data revealed strong consensus across all teams. The triadic partnerships were reported to help reduce feeling “distance” learning. Throug...

When human alveolar macrophages (AM) lavaged from healthy donors were incubated in medium with or without lipopolysaccharide (LPS) or muramyl dipeptide, they released a factor(s) responsible for tumor cell killing. The activity of the tumor cytolytic factor(s), called TCF, was determined by radioactive release assay. Human AM released variable amounts of TCF into the culture medium without any ...

Previous examination of the effect of TCF-4 on transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in human astrocytic cells found that TCF-4 affects the HIV-1 promoter through the GC-rich domain (nt -80 to nt -68). Here, the physical interaction and a functional consequence of TCF4-Sp1 contact were characterized. It was shown that expression of TCF-4 in U-87 MG (human ast...

The relationships between the intensification rate (IR) and size configuration of tropical cyclones (TCs) are investigated. Theoretically, intensity, configuration, relative vorticity TCs intrinsically linked. TC fullness (TCF) is used to quantify can be expressed as product critical (TCF0) ratio (Rf). TCF0 represents fundamental constraint on shared by at a given intensity lower limit fullness...

Scholars of street-level bureaucracy and institutional research focus primarily on the relationships between advocates their larger bureaucratic social systems, assuming that have little need to satisfy beneficiaries. We find otherwise in our two-year ethnographic study public defenders advocating for disadvantaged clients interactions with district attorneys. In analysis 82 advocacy opportunit...