Traumatic brain injury is considered as one of the main causes of morbidity and mortality worldwide. Apart from primary mechanical injury, Secondary injuries due to inflammation and apoptosis result in great neuronal damage. Current treatments are not able to regenerate the damaged part and prevent future sequels. Using human stem cells with self-assembling scaffolds may be promising in treatme...

Introduction: It has been suggested physical exercise exerts neuroprotection in traumatic brain injury (TBI). However little information is available about the effect of endurance exercise on brain edema, inflammation and oxidant activity in diffuse TBI. Therefore, we investigated the prophylaxis effect of endurance training against oxidative damage, inflammation and brain edema assoc...

Objective(s): -methyl-D-aspartate NMDA receptor (NMDAR) and aquaporin 4 (AQP4) are involved in the molecular cascade of edema after traumatic brain injury (TBI) and are potential targets of studies in pharmacology and medicine. However, their association and interactions are still unknown.Materials and Methods: We established a rat TBI model in this study. The cellular distribution patterns of ...

OBJECTIVE To examine how pre-traumatic brain injury (TBI) variables and TBI-related characteristics predict post-TBI criminal arrest, using longitudinal data from the Traumatic Brain Injury Model System National Database. SETTINGS Medical hospitals; rehabilitation facilities. PARTICIPANTS Participants with documented TBI and nonmissing Traumatic Brain Injury Model System data, resulting in ...

Traumatic brain injury (TBI) is a silent epidemic. Mild traumatic brain injury (mTBI) causes brain injury that results in electrophysiologic abnormalities visible on electroencephalography (EEG) recordings. The purpose of this brief review was to discuss the importance of EEG findings in traumatic brain injury. Relevant articles published during the 1996-2016 period were retrieved from Medline ...

Brain injury is a significant risk factor for chronic gliosis and neurodegenerative diseases. Currently, no treatment available neuroinflammation caused by the action of glial cells following brain injury. In this study, we investigated quinpirole-mediated activation dopamine D2 receptors (D2R) in mouse model traumatic (TBI). We also neuroprotective effects quinpirole (a D2R agonist) against ce...

Traumatic brain injury (TBI) is amongst the leading causes of morbidity and mortality worldwide. Despite evidence neurogenesis post-TBI, survival integration newborn neurons remains impaired. High Mobility Group Box protein 1 (HMGB1) an ‘alarmin’ released hyper-acutely following TBI implicated in hosting neuro-inflammatory response to injury. It also instrumental mediating under physiological c...

Traumatic cerebral vascular injury (TCVI) is a frequent, perhaps universal, feature after traumatic brain injury (TBI) and may be responsible for for some TBI-related chronic disabilities. Because there are multiple pharmacologic and non-pharmacologic therapies that promote vascular health, TCVI is an attractive target for therapeutic intervention after TBI. The cerebral microvasculature (CMV) ...