The Rockefeller University Press $30.00 J. Cell Biol. Vol. 209 No. 1 97–110 www.jcb.org/cgi/doi/10.1083/jcb.201408027 JCB 97 Correspondence to Yuxin Mao: [email protected] Abbreviation used in this paper: CCP, clathrin-coated pit; CI-M6PR, cationindependent mannose 6-phosphate receptor; CRISPR, clustered regularly interspaced short palindromic repeats; hSac2, homology Sac2; N2A, Neuro-2A; OCRL,...

Per-trochanteric (4 Part) fractures of femur are commonest in elderly people. The incidence is expected to increase in the coming years, with an ageing population resulting in a greater number of traumatic injuries in patients with osteoporotic bone. DHS fixation is gold standard modality for treatment of such fractures. Various implants used for such fractures are 1) DHS Sliding compression sc...

Recently Abbasbandy and Hajjari (Computers and Mathematics with Applications57 (2009) 413-419) have introduced a ranking method for the trapezoidalfuzzy numbers. This paper extends theirs method to all fuzzy numbers,which uses from a defuzzication of fuzzy numbers and a general weightingfunction. Extended method is interesting for ranking all fuzzy numbers, and itcan be applied for solving and ...

Thin-film composite (TFC) membranes show great potential in dye nanofiltration but their performance still required further improvement. In this work, ultra-small EMT zeolite nanocrystals were embedded into the interfacial polymerized polyamide (PA) layer supported on porous nylon via spray dispersion method and used separation. Ultra-small nanosized crystals with plate-like morphology synthesi...

The lack of mechanistic insights into the water and solute transport in thin film nanocomposite (TFN) membrane active layer posed a major challenge fundamental understandings performance optimization such membranes treatment. In this work, we develop novel model to qualitatively quantitatively study influence intrinsic permeabilities geometric parameters NPs NPs-polymer intermediate on widely o...

The fuzzy regression control chart is a functional technique to evaluate the process in which the average has a trend and the data represents a linguistic or approximate value. In this study, the theoretical structure of the “α-level fuzzy midrange for α-cut fuzzy X ~ -regression control chart” is proposed for triangular (TFN) and trapezoidal (TrFN) membership functions. In addition, the real w...

Direct implementation of extended arithmetic operators on fuzzy numbers is computationally complex. Implementation of the extension principle is equivalent to solving a nonlinear programming problem. To overcome this difficulty many applications limit the membership functions to certain shapes, usually either triangular fuzzy numbers (TFN) or trapezoidal fuzzy numbers (TrFN). Then calculation o...

Autophagy is a bulk degradation process characterized by the formation of double membrane vesicles called autophagosomes. The exact molecular mechanism of autophagosome formation and the origin of the autophagosomal membrane remain unclear. We screened 38 human Tre-2/Bub2/Cdc16 domain-containing Rab guanosine triphosphatase-activating proteins (GAPs) and identified 11 negative regulators of sta...