The risk of renal transplant recipients to develope malignant disease is significantly higher than these in general population. The incidence of malignancy is estimated to be around 1520% of renal recipients 10 years after renal transplantation and increases as high as 49.6% after 20 years.(Alberu, 2010; Kapoor, 2008; Penn, 2000; Gaya, et al, 1995). The most common malignancies are skin carcino...

INTRODUCTION Powerful immunosuppressive regimens have reduced rejection risk, leading to an expanding cohort of long-term kidney transplant recipients who are likely to encounter practitioners in other specialties. SOURCES OF DATA Key review papers and primary literature identified through searches of PubMed, Google Scholar and Medline. AREAS OF AGREEMENT Death from cardiovascular disease a...

BACKGROUND Patients undergoing renal transplant procedures require multi-agent immunosuppressive regimens both short term (induction phase) and long term (maintenance phase) to minimize the risk of organ rejection. There are several drug classes and agents for immunosuppression. Use of these agents may increase the risk of different harms including not only infections, but also malignancies inc...

The occurrence of secondary neoplasms in adult patients treated with chemotherapy childhood is not uncommon. Prior found to be an independent risk factor for the development malignancies, which are usually associated a worse prognosis. presented case 35-year-old female patient who was diagnosed Ewing sarcoma her late adolescence. tumor successfully chemotherapy, but 3 years later she T-cell lym...

BACKGROUND Lung transplant is the only available therapy for patients with advanced lung disease. The goal of this study was to examine the prevalence, origin, management and outcome of lung cancer in recipients of lung transplant at our institution. METHODS After institutional review board approval, we conducted a retrospective chart review of all lung transplantations in our institution fro...

Malignancy has become one of the three major causes of death after transplantation in the past decade and is thus increasingly important in all organ transplant programs. Death from cardiovascular disease and infection are both decreasing in frequency from a combination of screening, prophylaxis, aggressive risk factor management, and interventional therapies. Cancer, on the other hand, is poor...

Renal transplantation increases the probability of malignant tumors by about 2-4-fold overall with a much higher rate for renal epithelial malignancy. Renal tumors in renal transplant recipients are commonly conventional clear cell or papillary renal cell carcinoma. Clear cell papillary renal cell carcinoma is a recently described unique renal epithelial neoplasm with scant eosinophilic or mode...

The success of renal transplantation may be counterbalanced by serious adverse medical events. The effect of immunosuppression on the incidence of de novo neoplasms among kidney recipients should be monitored continuously. Using data from the Scientific Registry of Transplant Recipients, we studied the association of induction therapy by immunosuppression with antilymphocyte antibodies, with th...

Skin cancer in organ transplant recipients is a serious problem that manifests as increased squamous cell carcinoma in longterm patients. In these patients, a combination of cumulative sun exposure as well as the immunosuppressive effects of transplant medications can cause cutaneous malignancy. Skin cancer can affect transplant patients in multiple ways. It can decrease quality of life by caus...