BACKGROUND Elevation of FSH is frequently a consequence of impaired ovarian follicle growth. Down-regulation of the FSH levels by inhibins is mediated through its receptor betaglycan in the gonadotrophs. Understanding of germline status of the betaglycan gene (TGFBR3) is essential for ovarian failure pathophysiology. METHODS Sequence analysis was performed for the coding region of TGFBR3 gene...

Premature Ovarian Failure (POF) defined as functional stop of ovaries before the age of 40. It is a common cause of infertility in women that characterized by primary or secondary amenorrhea, high gonadotropin levels and estrogen level declining in patients. Factors that reduce follicle or defect in the follicle growth stimulating mechanism defined as numerous complication factors that they can...

Background Ovarian tissue cryopreservation is an option for patients who require immediate gonagonadotoxic treatment of cancers. when there is insufficient time to conduct ovulation induction This procedure can be used in patients with genetic mutations with a high risk for premature ovarian failure.This strategy is the only option for fertility preservation in prepubertal girls or in women who...

Introduction: Premature Ovarian Failure (POF) is cessation of ovarian functions before the age of 40 years old with consequent cessation of menstruation. Objective of study: The aim of this study was to evaluate the association between Premature Ovarian Failure and sexual dysfunctions and outcome of management with tibolone. Patients and Methods: Thirty-one women with Premature Ovarian Failure ...

objective: to determine the efficacy of ovarian drilling in pco patients who failed to achieve pregnancy with medical treatment. methods and main results: 75 patients with a diagnosis of pco of whom 48(64%) were primary infertile and 27(36%) were secondary infertile were clomiphene resistant. the other methods like bromocriptin, gonadotropins, gnrh -a and metformin had been given to these patie...

Recent advances in the technology of vitrification of human oocytes and embryos have increased the opportunities for fertility preservation in cancer patients. Ovarian stimulation in this group of patients is associated with some unique challenges. A controversy in this field rotated around the hypothesis that the transient elevations of estrogen during an IVF cycle may stimulate tumor growth; ...

Ovarian cancer has the poorest prognosis among all gynecological cancers. 1,2 Besides the concealed onset of ovarian cancer and the high tendency to abdominal dissemination and metastasis, frequent recurrence and resistance to chemotherapy are also the main reasons for treatment failure of ovarian cancer. A large number of clinical trials proved that platinum­based chemotherapy plus paclitaxel ...