Abstract Transfusion-related acute lung injury (TRALI) is a hazardous transfusion complication with an associated mortality of 5% to 15%. We previously showed that stored (5 days) but not fresh platelets (1 day) cause TRALI via ceramide-mediated endothelial barrier dysfunction. As biological ceramides are hydrophobic, extracellular vesicles (EVs) may be required shuttle these sphingolipids from...

1 Royal Australasian College of Surgeons. Surgical Education and Training program. Melbourne: RACS, 2007. http://www.surgeons.org/Content/NavigationMenu/EducationandTraining (accessed Oct 2007). 2 Royal Australasian College of Surgeons. Council highlights August 2007. Melbourne: RACS, 2007. http://www.surgeons.org/Content/NavigationMenu/WhoWeAre/Council/CouncilHighlights/Council_Highlights_Augu...

β-thalassemia, a congenital genetic hematological disorder characterized by the decrease or absence of β-globin chains, leads to in levels Hemoglobin A. The affected individuals can be categorized into two cohorts based on transfusion dependency: transfusion-dependent thalassemia (TDT) and non-transfusion-dependent (NTDT). Remarkably, despite primary pathology lying chain depletion, β-thalassem...

AIMS To study the prevalence and severity of liver diseases of transfusion dependent thalassaemia major patients, and correlate the histological and biochemical changes of iron overload in liver with the peripheral blood markers. METHOD Liver biopsy was performed to assess the histological changes and liver iron content (LIC). RESULTS One hundred patients were evaluated (median age 11.7 yea...

Endothelial dysfunction is prevalent in chronic kidney disease. This study tested the hypothesis that transfusion of rat aortic endothelial cells (ECs) ameliorates endothelial dysfunction in a rat model of chronic kidney disease. Male Sprague-Dawley rats underwent sham surgery or 5/6 nephrectomy (Nx). Five weeks after Nx, EC (1.5 × 10(6) cells/rat) or vehicle were transfused intravenously. One ...

introduction: the thalassamias refer to a diverse group of hemoglobin disorders characterized by a reduced synthesis of  one or more of globin chains (α,β, γ, δβ,γδβ, δ and εγδβ).the main cure available today for thalassamia is bone marrow transplantation (bmt)  from compatible donor.on december 3, 1981 a 14-month-old child with β-thalassemia major recieved bmt from his hla-identical sister in ...

The risk of HBV infection by blood transfusion remains moderate due to the prevalence of HBV carriers in the general population of Peninsular Malaysia ranging from 3 to 6%. 23% of multitransfused thalassaemics showed HbsAg and 31% have been exposed to HBV infection. I Hepatitis B vaccination should be carried out at the start of blood transfusion in all thalassaeI mics destined to be transfusio...