26 27 Two bacterial species, Pseudomonas aeruginosa and Lactococcus lactis, with different 28 metabolic features, were used as a comparative experimental model to investigate the antimicrobial 29 target and mechanism of transferrins. In anaerobiosis, P. aeruginosa cells were not susceptible to 30 lactoferrin (hLf) or transferrin (hTf). In aerobiosis, the cells were susceptible but O2-consumptio...

In a previous paper [Lindley et al. (1993), Acta Cryst. D49, 292-304], the X-ray structure analysis of the 18 kDa fragment of duck ovotransferrin, corresponding to the NII domain of the intact protein, was reported at a resolution of 2.3 A. In this structure, the Fe(III) cation binds to two tyrosine residues and the synergistic carbonate anion in an identical manner to that found in the intact ...

26 27 Two bacterial species, Pseudomonas aeruginosa and Lactococcus lactis, with different 28 metabolic features, were used as a comparative experimental model to investigate the antimicrobial 29 target and mechanism of transferrins. In anaerobiosis, P. aeruginosa cells were not susceptible to 30 lactoferrin (hLf) or transferrin (hTf). In aerobiosis, the cells were susceptible but O2-consumptio...

The effect of transferrins on hydroxyl radical formation from the superoxide anion and hydrogen peroxide generated by the xanthine-xanthine oxidase system has been studied by EPR using 5,5-dimethyl-1-pyrroline N-oxide as a spin trap. Neither diferriclactoferrin nor diferrictransferrin were found capable of promoting hydroxyl radical formation via the Haber-Weiss reaction even in the presence of...