BACKGROUND Rivastigmine is the only cholinesterase inhibitor (ChEI) available as transdermal patch. The patch was developed to improve gastrointestinal tolerability and treatment adherence to higher dosages as compared with oral medication. Preferences of patients and caregivers for the patch were reported; however, neither patient compliance nor caregiver burden has yet been measured under rou...

Oxybutynin is an efficacious treatment for overactive bladder, but its clinical utility is hampered by relative intolerability due to its side effect profile. Over the last few years, various attempts to enhance the tolerability of oxybutynin by varying the drug delivery mechanism have been introduced and have included extended release, rectal suppository, transdermal patch, and gel formulation...

Pain is a prevalent condition in patients with cancer, particularly in advanced stages of cancer. Although strong opioids are the mainstay of cancer pain management protocols, patients are often undertreated. Transdermal buprenorphine is currently available for the treatment of moderate to severe cancer pain and severe pain which does not respond to nonopioid analgesics; patch doses of 35, 52.5...

Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer’s disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug. The content of the drug was determined by High Performance Liquid Chromatography (HPLC) method. The morphology and size range of the microparticles ...

OBJECTIVE To study cycle control, compliance and safety of a transdermal contraceptive patch in Thai women. MATERIAL AND METHOD Sixty-nine healthy women were assigned to receive 3 cycles of contraceptive patch (ethinyl estradiol 20 microg and norelgestromin 150 miccrog/day). All participants aged 18-45 years were invited to participate at the family planning clinic at King Chulalongkorn Memor...

A matrix-type transdermal therapeutic system was developed for treating diseases of the eye where it is difficult for drug molecules to reach with conventional topical instillation. Prednisolone was employed as a model drug. An in vivo study using rats showed that the daily application of the patch maintained a constant plasma concentration of the drug, which was equivalent the therapeutic plas...

Pharmacognosy Research,2023,15,1,64-70.DOI:10.5530/097484900244Published:December 2022Type:Original ArticleAuthors:Poojashree Verma, Neelesh Maheshwari, and Deepika Bairagee Author(s) affiliations:Poojashree Verma1, Maheshwari2, Bairagee1,* 1Faculty of Pharmacy, PAHER University, Udaipur, Rajasthan, INDIA. 2School Sangam Bhilwara, Abstract:Aim: The present research aimed to formulate a transder...

As part of a programme for the implementation of a Smoking Control Policy in our hospital, an open study, without randomization, of 65 hospital workers, who wanted to give up smoking, was carried out. The characteristics of smoking in each subject were recorded. The Fagerstrom Questionnaire was used to measure the degree of dependence on nicotine. The treatment consisted of the daily use of 16 ...

Commentary The updated systematic review by Cahill and colleagues has several new findings that are useful for clinicians. First, cytisine, a low-cost plant-derived agent from Eastern Europe, had a modest increase in quit rates across 2 high-quality trials. A previous review found that earlier trials were of low quality (1), and publication bias is likely given that the drug had been studied in...