Motivated by investigations of the tridiagonal pairs of linear transformations, we introduce the augmented tridiagonal algebra Tq. This is an infinite-dimensional associative C-algebra with 1. We classify the finite-dimensional irreducible representations of Tq. All such representations are explicitly constructed via embeddings of Tq into the Uq(sl2)-loop algebra. As an application, tridiagonal...

BACKGROUND Human tuberculosis, which is caused by the pathogen Mycobacterium tuberculosis, remains a major public health concern. Increasing drug resistance poses a threat of disease resurgence and continues to cause considerable mortality worldwide, which necessitates the development of new drugs with improved efficacy. Thymoquinone (TQ), an essential compound of Nigella sativa, was previously...

Purpose: To investigate the potential genoprotective effects of thymoquinone (TQ) on the cytotoxicity and genotoxicity-induced by doxorubicin (DXR), a key chemotherapeutic drug. Methods: Isolated human peripheral leukocytes were treated with varying concentrations of TQ (5.0, 10.0, or 20.0 μM) alone or in combination with DXR (0.15 μg/mL). Comet assays and apoptotic cell studies were performed ...

Using the matrix Riemann-Hilbert factorisation approach for non-linear evolution systems which take the form of Lax-pair isospectral deformations, the higher order asymptotics as t→±∞ (x/t∼O(1)) of the solution to the Cauchy problem for the modified non-linear Schrödinger equation, i∂tu+ 1 2 ∂ x u+ |u|u+is∂x(|u|u) = 0, s ∈ R>0, which is a model for non-linear pulse propagation in optical fibres...

The Fagerström Tolerance Questionnaire (TQ) is often used in both research and treatment contexts to evaluate nicotine tolerance and physiological dependence in cigarette smokers. Recently, however, questions about its validity and its usefulness in comparison to other easily collected measures have been raised. In the present study, 100 male subjects reporting for experimental sessions (Sample...

BACKGROUND Ovarian cancer is the most lethal gynecologic malignancy characterized by the frequent development of resistance to platinum chemotherapy. Finding new drug combinations to overcome platinum resistance is a key clinical challenge. Thymoquinone (TQ) is a component of black seed oil that exerts multiple anti-tumorigenic effects on cells, including inhibition of NF-κB and promotion of DN...

Objective: Liver fibrosis is the primary sign of chronic liver injury induced by various causes. Thymoquinone (TQ) is the major ingredient of Nigella sativa with several beneficial effects on the body. In the present study, we aimed to investigate the effect of TQ on liver fibrosis in a lipopolysaccharide (LPS)-induced inflammation in male rats. Materials and methods: Fifty male Wistar rats wer...

OBJECTIVES Acrylamide (ACR) has broad applications in different industries. It also forms in food during heating process. Oxidative stress has a critical role in ACR-induced neurotoxicity in both in vitro and in vivo models; therefore, the aim of the current study was the evaluation of effects of thymoquinone, the main constituent of volatile oil from Nigella sativa seeds in ACR-induced neuroto...

Thymoquinone (TQ) is a bioactive component of black seed (Nigella sativa) volatile oil and has been shown to have anti-oxidative, anti-inflammatory, and anti-cancer properties. In the present study, we explored the molecular mechanisms that underlie the anti-inflammatory effect of TQ and its target proteins using lipopolysaccharide (LPS)-stimulated murine macrophage-like RAW264.7 and human mono...

The radial density profile of pre-thermal quench (pre-TQ) early-time non-thermal (hot) electrons is estimated by combining electron cyclotron emission and soft x-ray data during the rapid shutdown low-density ( n e ? 10 19 m ? 3 ) DIII-D target plasmas with cryogenic argon pellet injection. This technique mostly limited in these experiments to pre-TQ phase quickly loses validity TQ. Two differe...