Pesticides can cause gene mutations and chromosomal aberrations in exposed individuals. We have investigated 24 workers exposed to pesticides. Clinical examinations and cytogenetic and toxicological tests were performed. Ten non-exposed individuals were used as controls. Toxicological dosages of copper, zinc and manganese (metals found in some pesticides), hepatic enzyme dosage (GOT, GPT, AR) a...

BACKGROUND Epidemiological, controlled human exposure, and toxicological studies have demonstrated a variety of health effects in response to particulate matter (PM) exposure with some of these studies indicating that populations with certain characteristics may be disproportionately affected. OBJECTIVE To identify populations potentially at greatest risk for PM-related health effects, we eva...

Cephradine, a semisynthetic cephalosporin antibiotic, has a low order of oral and parenteral toxicity in animals. The oral LD(50) in mice and rats ranged from 5 to >8 g/kg, and the intraperitoneal LD(50) values in mice and rats were 0.7 to 1.5 g/kg and 4.0 g/kg, respectively. The intravenous LD(50) in mice ranged from 3.0 to 3.8 g/kg. In anesthetized dogs, intravenous doses of cephradine (40 an...

Methanolic extract of Hairs and Glands covering fruits of Mallotus philippinensis (kamala powder) were subjected to Antimicrobial and toxicological screening. Antimicrobial profile indicated that extract was effective against all Gram positive cocci and bacilli used in the study. Among Gram negative bacilli, three important pathogenic species i.e. Salmonella typhi, Salmonella para typhiA and Ps...

Erythritol has been used since 1990 in Japan as a component of candies, sugar substitutes, chocolates, Erythritol is a four-carbon sugar alcohol (polyol) that soft drinks, chewing gum, jellies, jams, and yogurt has a sweetness 60 to 80% that of sucrose (Sugita and (Mitsubishi and Nikken, 1996). These uses amount to Yamazaki, 1988; Goossens and Röper, 1994) and is ina per capita consumption in J...

Genetic differences in response to chemicals are probably ubiquitous. The implications of such genetic differences for the design of toxicological experiments is reviewed. The inclusion of genetic differences as factors in factorial experimental designs is illustrated by an experiment to investigate differences between inbred strains of mice in the length of anaesthesia following the administra...

In this work phytochemical, pharmacological and toxicological studies were carried out on Eruca saliva,Petroselinum crispum and Anethum graveolens alcoholic extract. LDso of these extracts can not be detected, when given orally in mice. These alcoholic extracts inhibit rabbit's intestinal motility . Eruca sativa extract stimulates the uterine motility of all stages of sex cycle, while Petroseli...

In the present study, changes in velocity of cytoplasmic streaming in the giant internodal cells of Nitella for varying concentration of the pesticides, 2,4-D, dieldrin, malathion, methyl parathion and endosulfan, were measured. Marked decrease in the velocity of cytoplasmic streaming was found at the concentrations of 0.01, 0.1, 1, 10 and 100mM. Dieldrin was the most toxic to all the pesticide...

A range of contaminants including carcinogens, metals, bio-toxins, and persistent organic pollutants injure livers of fishes, and although some mechanisms of liver injury are unique to fish, most of the hepatic injury in these aquatic vertebrates arises from mechanisms similar to those observed in mammals [2]. An understanding of chemical hepato-toxicity requires an appreciation of anatomic and...