Floating matrix tablets of Glimepiride were developed to enhance its bioavailability by prolonging the gastric residence time in which Glimepiride was chosen as a model drug because of its has incomplete absorption due to its low gastric residence time. Floating matrix tablets were prepared using melt granulation technique. Bees wax was used as a hydrophobic meltable material. Hydroxypropylmeth...

Floating matrix tablets of Cephalexin were prepared by using synthetic and natural polymers each in two different concentrations. The floating properties and in-vitro drug release properties were optimized and total 10 formulations were developed. The synthetic and natural polymers used were HPMC K4M, HPMC K15M and Guar Gum, Xanthan gum respectively. Each formulation consists of polymer in any ...

The present investigation was aimed to formulate and evaluate the gastro-retentive floating microballoons of glipizide using hydrophilic polymers hydroxypropyl methylcellulose (HPMC) and Eudragit RS100 (RS 100) by emulsion solvent evaporation technique. The floating microballoons were evaluated using micromeritic properties, buoyancy, in vitro drug release, scanning electron microscopy and stab...

The Table Maker’s Dilemma is the problem of always getting correctly rounded results when computing the elementary functions. After a brief presentation of this problem, we present new developments that have helped us to solve this problem for the double-precision exponential function in a small domain. These new results show that this problem can be solved, at least for the double-precision fo...

The objective of this study was to evaluate the effect of formulation variables on the release properties, floating lag time, and hardness, when developing floating tablets of Ranitidine hydrochloride, by the statistical optimization technique. The formulations were prepared based on 3(2) factorial design, with polymer ratio (HPMC 100 KM: Xanthan gum) and the amount of aerosil, as two independe...

Specific : buoyancy, clinical study, cut-off size, dimension monitoring, dosage form size, floating dosage form, floating force, gamma scintigraphy triple radiolabeling and monitoring technique, gastric emptying, gastric residence time, Hydrodynamically Balanced System (HBS), intragastric buoyancy, monolithic hydrophilic matrix, non-floating dosage form, resultant-weight measuring apparatus and...

Processing floating point division generally consists of SRT recurrence, quotient conversion, rounding, and normalization steps. In the rounding step, a high speed adder is required for increment operation, increasing the overall execution time. In this paper, a floating point divider performing quotient conversion and rounding in parallel is presented by analyzing the operational characteristi...

Callitriche cophocarpa Sendtner is a heterophyllous amphibious macrophyte that produces apical rosettes of floating leaves. The importance of air contact for inorganic carbon and N uptake and for growth was investigated. Plants were grown with the floating rosette in contact with air of various humidities (10, 50, and >90% relative humidity) and with the submerged parts in N-free water at 350 [...

INTRODUCTION Absorption of drugs through the gastrointestinal tract poses a variety of limitations, making the in vivo performance of drug delivery systems uncertain. Following on from recent advances, in a time of increased consideration of floating drug delivery systems, it is as important as ever to continue the progress by studying different aspects of these systems. Moreover, it seems impe...