Antimicrobials that are associated with QT prolongation include the. Torsades de pointes (TdP), a potentially fatal polymorphic ventricular. . are more susceptible to the effects of these small changes than are others [17, 18].. As a result of increased exposure to an IKr-blocking agent, risk of TdP may increase [ 26, 27].

Flecainide has been known to cause torsades de pointes (TdP) in patients with structural heart disease and its mechanism has been attributed to use-dependency. We present a patient with flecainide-induced TdP in the absence of any other precipitating factors. This case highlights potential reverse use dependence associated with flecainide resulting in TdP.

We conclude that coronary anatomy is independent of the human genome. Disease lesion sites are at least partly independent of the human genome. In contrast, age at first cardiac event, type of cardiac event and risk factor profile appear to be more closely related to genetic profile. We suggest that when one twin presents with IHD, the second should be subject to increased medical surveillance ...

Marked prolongation of the QT interval on the electrocardiogram associated with the polymorphic ventricular tachycardia Torsades de Pointes is a serious adverse event during treatment with antiarrhythmic drugs and other culprit medications, and is a common cause for drug relabeling and withdrawal. Although clinical risk factors have been identified, the syndrome remains unpredictable in an indi...

sades de pointes due to quinidine: observations in 31 patients. Am Hearf J 1984; 107:425-%30. 2. Roden DM, Woosley RL, Primm RK. Incidence and clinical features of the quinidine-associated long QT syndrome: implications for patient care. Am Heart J 1986; 111:1088-1093. 3 Coplen SE, Antman EM, Berlin JA, Hewitt P, Chalmers TC. Efficacy and safety of quinidine therapy for maintenance of sinus rhy...

Torsades de pointes is a life-threatening arrhythmia associated with a number of causes, but is very rare among endocrinologic disorders. We report a case of male pseudohermaphroditism with hyperaldosteronism due to a 17α-hydroxylase deficiency presented with sudden cardiac arrest.