PURPOSE Various therapeutic approaches have been suggested for preventing or reducing the adverse effects of topical glucocorticoids, including skin barrier impairment. Previously, we have shown that impairment of skin barrier function by the highest potency topical glucocorticoid, clobetasol 17-propinate (CP), can be partially prevented by co-application of a physiological lipid mixture contai...

OBJECTIVES To evaluate the comparative efficacy and tolerability of topical calcipotriol in the treatment of mild to moderate chronic plaque psoriasis. DESIGN Quantitative systematic review of randomised controlled trials. SUBJECTS 6038 patients with plaque psoriasis reported in 37 trials. MAIN OUTCOME MEASURES Mean difference in percentage change in scores on psoriasis area and severity ...

BACKGROUND AND OBJECTIVE In 1972, Dumas and Scholtz developed the psoriasis plaque test to evaluate the potency of local corticosteroids. Through further modification of this method, the efficacy between antipsoriatic products can be differentiated. This method allowed for the simultaneous application of several products to different test sites in the same psoriasis patient. The objective of th...

this study aimed to compare the efficacy of dexamethasone and hydrocortisone in the treatment of acute paediatric asthma. forty seven asthmatic children were randomised to receive either dexamethasone (0.6 mg/ml, maximum 16 mg) in a single dose or hydrocortisone (8-10 mg/kg/day) in 4 equal doses for 2 days. our findings showed that the mean length of hospitalization in children receiving dexame...

A high airway concentration might be required for the antiasthmatic efficacy of inhaled glucocorticosteroids (GCS). The topical uptake and retention of GCS in airway tissue were compared for GCS of the inhaled type [budesonide (BUD), fluticasone propionate (FP), and beclomethasone dipropionate (BDP)] and of the noninhaled type (dexamethasone and hydrocortisone). 3H-labeled GCS solutions were ad...

IMPORTANCE Alopecia areata is an idiopathic cause of hair loss with limited therapeutic repertoire. OBJECTIVE To compare the efficacy and safety of a high- vs low-potency topical corticosteroid in pediatric patients. DESIGN, SETTING, AND PARTICIPANTS This single-center, randomized, blind, 2-arm, parallel-group, superiority trial was carried out over a 24-week period at a tertiary referral a...

The goal of hormone replacement is to mirror physiology. Hydrocortisone granules and modified release formulations are being developed optimise cortisol in the rare disease adrenal insufficiency. To facilitate clinical development, we built verified a physiologically based pharmacokinetic (PBPK) model for endogenous (hydrocortisone) healthy adults, children adults with predicted immediate-relea...

INTRODUCTION We report on a double-blind, vehicle-controlled, single-center confirmatory study with random assignment. The purpose of the study was to investigate the topical bioavailability of different topical corticosteroid formulations in healthy human beings focussing on desoximetasone (DM). MATERIALS AND METHODS Two DM 0.25% formulations [ointment (DM-o) and fatty ointment (DM-fo, water...

BACKGROUND Mastocytosis is a rare disorder with diverse clinical manifestations. In cutaneous mastocytosis the mast cell infiltration is limited to the skin, but is often associated with systemic symptoms due to the release of mast cell mediators. CASE REPORT We report a 6-month-old male infant who had skin lesions of various morphologies (macules, papules, plaques, and nodules) and sizes, pe...