The aim of the study was to examine the effect of topical vehicles on the in vivo human stratum corneum penetration of the antioxidant and skin photoprotective agent (-)-epigallocatechin-3-gallate (EGCG). Model oil-in-water (o/w) emulsion and gel formulations containing 1 % (m/m) EGCG were prepared and subjected to photodegradation studies in order to select excipients that minimize the light i...

    Topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. The new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. The adhesive capacity of hydroxypropyl methylcellulose (HPMC) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling test...

Introduction: Anal fissures are small tears in the lining skin of the anus presenting with typical symptoms of pain and bleeding during defecation. Several new forms of medicines such as glyceryle trinitrate (GTN) ointments and diltiazem, a calcium channel-blocking agent, have been recently used for the treatment of these fissures. Diltiazem relaxes the muscle of anal sphincter and consequently...

BACKGROUND Systemic and topical antimicrobials are effective in the treatment of inflammatory acne vulgaris; however, widespread use of these agents is becoming increasingly associated with the emergence of resistant pathogens raising concerns about microorganism resistance and highlighting the need for alternative nonantimicrobial agents for the treatment of acne. Nicotinamide gel provides pot...

Background and objectives: Plants are usually used for treatment of different diseases according to their traditional application. The use of the plant based medications is increasingly becoming popular all over the world. Traditional herbal medicines should be transformed into new forms to make better acceptance and more comfortable use by patients. The aim of the present stud...

    Topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. The new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. The adhesive capacity of hydroxypropyl methylcellulose (HPMC) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling test...

The in vitro fluoride uptake by dental enamel from two conventional acidulated phosphate fluoride gels was compared to a thixotropic acidulated phosphate fluoride gel. The fluoride concentration and enamel biopsy depths were determined using an acid-etch biopsy method based on calcium determinations. A significant fluoride uptake by dental enamel from a thixotropic topical fluoride agent follow...

topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. the new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. the adhesive capacity of hydroxypropyl methylcellulose (hpmc) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling tester. ...

Purpose: This report gives findings from an (ongoing) Phase 1b, escalating dose, clinical trial, assessing the safety and tolerability of VT30 Topical Gel as a treatment for venous, lymphatic mixed venolymphatic lesions skin (VM, LM VLM, respectively), driven by inappropriate activation intracellular PI3K. Methods: After giving informed consent completing screening evaluations that included con...