Tacrolimus (TAC) suspension is used to treat moderate severe atopic keratoconjunctivitis (AKC) and vernal (VKC). The objectives of this study were formulate the hydrophobic compound TAC in an aqueous eye drop formulation its ocular biodistribution on topical application a healthy rabbit model, with overall aim using AKC VKC. A thin-film hydration method was encapsulate within chitosan-based amp...

Background: Lidocaine is a local anesthetic and antiarrhythmic agent. There are reports on accidental and intentional cases of poisoning following injection of lidocaine while rare are the fatal cases realized after oral ingestion of lidocaine. Suicidal poisoning with lidocaine pharmaceutical formulations is rare since no pharmaceutical dosage forms for oral use are available except gels and sp...

The aim of this double-blinded, vehicle-controlled study was to test the antipruritic efficacy of topical strontium to relieve a nonhistaminergic form of itch that would be clinically relevant for chronic pruritic diseases. Itch induced with cowhage is mediated by PAR2 receptors which are considered to play a major role in itch of atopic dermatitis and possibly other acute and chronic pruritic ...

introduction pharmacologic treatment of radicular pain with oral medications is limited by adverse effects and concern for dependence. while topical formulations have been explored in pain research, there is no published literature evaluating the efficacy in radicular pain. we present the first three cases of radicular pain successfully treated with a topical formulation of diclofenac, ibuprofe...

Topical corticosteroids have been the cornerstone of treatment over last six decades for various dermatoses characterized by dry, scaly, crusted, or erythematous skin as well those associated with inflammation and pruritus. The potency a topical steroid depends on specific molecule, amount drug reaching target, absorption through (0.25%–3%), formulation. Clobetasol propionate (CP) 0.025% cream ...

Objective: The present study was aimed to develop topical gel of Clobetasol propionate with the help of carbopol-934 and Hydroxypropyl methylcellulose K4m as gelling agents. Polymers play major role in various characterization parameters of topical gel such as in vitro release and rheological properties. Methods: Gels were prepared with carbopol-934 and Hydroxypropyl methylcellulose K4m as gell...

the water content of the epidermis is a main factor in maintaining skin smoothness and elasticity and preventing skin dryness. occlusive products can greatly affect skin hydration by forming a barrier on the skin following the topical administration of oil-based formulations. these products repair the skin barrier by restoring the skin lipids as well. solid lipid nanoparticles (slns) have recen...

the available minoxidil formulations for topical application suffer with major drawback having less contact time with the scalp which requires repeated application. hence, the present study was aimed to investigate the effect of microemulsions and microemulsion based hydrogel systems (mehs) for increased percutaneous penetration of minoxidil. minoxidil microemulsions were developed by following...

background the goal of the present study was the preparation and evaluation of griseofulvin topical gel as a drug dosage form with appropriate efficacy and stability. material and methods to select the best formulation, formulations with different concentration of carbomer and hpmc were evaluated for their appearance. then evaluated for physicochemical characteristics such as rheologic behavior...