In this paper we analyze the monotonicity of the time to peak response Tmax with respect to the drug dose D for the four different turnover models I IV, as introduced by Dayneka et al. [2]. We do this for the situation when the drug is supplied through an initial bolus, and eliminated according to a single exponential function and stimulation or inhibition takes place through a Hill function. W...

UNLABELLED We compared the effects of i.v. tramadol (1.25 mg/kg), codeine (1 mg/kg), morphine (0.125 mg/kg), and saline on gastric emptying in 10 healthy human volunteers using a double-blind, randomized, cross-over design. Subjects received one treatment at each of four sessions, 2 wk apart. Gastric emptying was studied using the paracetamol absorption test. There were significant differences ...

PURPOSE To investigate the association between intraoperative palm temperature change and the curative effect of sympathicotomy. METHODS 49 patients with palmar hyperhidrosis were treated with bilateral endoscopic sympathicotomy. Ipsilateral palm temperature was monitored before and at 3-5 min increments after the sympathetic trunk was transected. The maximum temperature elevation (Tmax) was ...

Studies were made on the relationships between the rate of glucose metabolism, the transport of glucose between plasma and brain, cerebral blood flow, and blood content. Conscious control rats were compared with rats with intense tremors induced with cismethrin. The influence of plasma glucose concentration was studied by fasting some animals overnight prior to the induction of tremors. Mean pl...

Fluoxetine drops and marketed fluoxetine capsules had quite the same Cmax (50.25 +/- 4.43 vs 47.55 +/- 5.29 ng/ml), but significantly different AUC0-t (717.27 +/- 71.29 vs 644.91 +/- 78.91 ng/ml/h). Furthermore the drops were characterised by a very early Tmax (4.61 +/- 0.85 hours) with a highly significant difference in comparison to the capsules reference compound (6.72 +/- 1.23 hours). After...

Defined as the difference between daily maximum (Tmax) and minimum surface air temperature (Tmin), diurnal range (DTR) is critical to local climate, ecosystem, socio-economic functioning. This study investigates how DTR responds future global warming, using a novel, fine-resolution convection-permitting regional climate model. Results demonstrate asymmetrical impact of that is, more substantial...

Climate change variables have rarely been analyzed specifically for the growing season of crops. In this study, changes in minimum (Tmin) and maximum temperature (Tmax), daily maximum saturated vapor pressure (VPsat) and estimated daily VPD weighted for transpiration (VPDtran) were examined at five locations in Iran over 40 years during the growing seasons of chickpea and maize. The results of ...

shift changes and heterogeneity analyses of hydro-climatic variables is very important in water resources planning and management. in order to shift changes and heterogeneity analyses of tmin and tmax, precipitation and discharge, 2, 7 and 7 stations was used over the 40 years (1972-2011), respectively. the results of annual tmin and tmax series showed that both of two stations had the signific...

The maximal value of thermal conductivity κmax of the perfect wurzite GaN crystal containing isotopes of natural abundance is estimated. Our upper limit of κ = 4800 W/Km at Tmax = 32 K is smaller than calculated by Liu and Balandin κ = 6000 W/Km and higher than obtained by Slack et al κ = 3750W/Km. The phenomenological dependence κ ∝ T obtained by Mion et al for the temperature interval 300− 45...