Tumor lysis syndrome (TLS) is a life-threatening oncologic complication caused by the lysis of a vast number of malignant cells resulting in metabolic derangements and organ dysfunction. TLS can occur spontaneously before initiation of any therapies often referred to as spontaneous tumor lysis syndrome (STLS), or shortly after the induction of chemotherapy, radiotherapy, or cytolytic antibody t...

TLS is by far the most important protocol on the Internet for negotiating secure session keys and providing authentication. Only very recently, the standard ciphersuites of TLS have been shown to provide provably secure guarantees under a new notion called Authenticated and Confidential Channel Establishment (ACCE) introduced by Jager et al. at CRYPTO’12. In this work, we analyse the variants o...

Translesion synthesis (TLS) enables DNA replication through damaged bases, increases cellular DNA damage tolerance, and maintains genomic stability. The sliding clamp PCNA and the adaptor polymerase Rev1 coordinate polymerase switching during TLS. The polymerases Pol η, ι, and κ insert nucleotides opposite damaged bases. Pol ζ, consisting of the catalytic subunit Rev3 and the regulatory subunit...

In a previous paper [Zhu et al., J. Opt. Soc. Am. A 14, 799 (1997)] an iterative algorithm for obtaining the total least-squares (TLS) solution of a linear system based on the Rayleigh quotient formulation was presented. Here we derive what to our knowledge are the first statistical properties of this solution. It is shown that the Rayleigh-quotient-form TLS (RQF-TLS) estimator is equivalent to...

In this study, individual tree height (TH), crown base height (CBH), crown area (CA) and crown volume (CV), which were considered as essential parameters for individual stem volume and biomass estimation, were estimated by both an airborne laser scanner (ALS) and a terrestrial laser scanner (TLS). These ALSand TLS-derived tree parameters were compared because TLS has been introduced as an instr...

BACKGROUND Despite the prophylactic use of allopurinol, tumor lysis syndrome (TLS)-related morbidity and mortality still occur in a number of patients with acute myeloid leukemia (AML). The aim of this study was: (i) to analyze the incidence and outcome of TLS in a large series of patients with AML receiving hyperhydration and allopurinol, (ii) to identify risk factors for TLS, and (iii) to dev...

Transport Layer Security (TLS) is a secure communication protocol that is used in many secure electronic applications. In order to establish a TLS connection, a client and server engage in a handshake, which usually involves the transmission of digital certificates. In this paper we present a practical speedup of TLS handshakes over bandwidth-constrained, high-latency (i.e. disadvantaged) links...

Translesion synthesis (TLS), the process by which DNA polymerases replicate through DNA lesions, is the source of most DNA damage-induced mutations. Sometimes TLS is carried out by classical DNA polymerases that have evolved to synthesize DNA on non-damaged templates. Most of the time, however, TLS is carried out by specialized non-classical DNA polymerases that have evolved to synthesize DNA o...