BACKGROUND Thyroid nodules are common, but only 5% of nodules are found to be malignant. In North America, the incidence of thyroid cancer is increasing. Fine needle aspirate (FNA) biopsy is the diagnostic test of choice. Unfortunately, up to 20% of FNAs are non-diagnostic. A specific molecular marker for thyroid cancer is desirable. Evidence suggests that cell signaling through transforming gr...

Background: Papillary thyroid carcinoma is the most common thyroid cancer (85%). Follicular thyroid carcinoma is the second most common type of thyroid cancer, accounting for up to 10% of all thyroid cancers. Medullary thyroid carcinoma accounts for only 5–8% of thyroid cancers. Concurrent medullary, follicular, and papillary carcinomas of the thyroid Received: April 22, 2014 Accepted after rev...

The aim of this study was to examine the expression of mucin 1 (MUC1) and c-myc and the significance thereof in elderly patients with papillary thyroid carcinoma. The expression levels of MUC1 and c-myc were examined by immunohistochemical methods in 58 patients with papillary thyroid carcinoma, 35 with nodular goiter, and 30 subjects with normal thyroid tissue. The positive rate of MUC1 detect...

BACKGROUND AND PURPOSE Workup of incidental thyroid nodules detected on CT imaging could be contributing to the increased diagnosis of small thyroid cancers. The purpose of this study was to evaluate recent trends in the incidence of thyroid cancer, and to determine the relationship between annual CT imaging volume and rate of thyroid cancer diagnosis. MATERIALS AND METHODS This retrospective...

Cyclin D1 is an important positive regulator of the G1/S phase of the cell cycle. We investigated the association between the CCND1 G870A polymorphism and susceptibility to papillary thyroid cancer in Turkish people. This study covered 102 patients with papillary thyroid cancer and 174 healthy controls. CCND1 genotyping was determined by the PCR-RFLP method. We found that the A allele frequency...

Follicular variant of papillary thyroid cancer typically favors nodal spread. We report a case with hematogenous spread including multi-organ involvement and describe our staged management approach. This is the first case to report follicular variant of papillary thyroid cancer with simultaneous adrenal and renal involvement.

Cancer of the thyroid gland is the most common endocrine malignancy constituting for less than 1% of all reported human cancers1. The propensity of occurrence of thyroid carcinomas is two to four times more in females as compared to males with a median age at diagnosis being 45–50 years [1,2]. Papillary thyroid carcinoma (PTC) is the most common histological type of thyroid cancer and accounts ...

Thyroid follicular epithelial cell–derived cancer includes papillary carcinoma, Hürthle cell poorly differentiated thyroid cancer, and anaplastic carcinoma. Although the incidence of has increased over past 30 years, there not been a significant increase in patient mortality. Use increasingly sensitive detection methods such as high-resolution imaging enabled earlier better characterization mal...

BACKGROUND This study investigates whether diabetes mellitus is a risk factor for the development of papillary thyroid cancer, using an age-, gender-, and race-matched analysis. METHODS We retrospectively reviewed the charts of 1559 patients with newly evaluated thyroid cancer over a 4-year period at our institution and identified 1313 patients (84%) with papillary thyroid carcinoma. Characte...

The aim of the present study was to confirm the frequency of microsatellite instability in thyroid cancers. We investigated 26 patients suffering from thyroid cancer (25 papillary carcinomas, 1 follicular carcinoma) using 8 microsatellite markers. Microsatellite instability (MSI) was found in two (7.7%) papillary carcinomas. Our data indicate that MSI is a relatively rare event and may seldom c...