Thrombocytosis is a common feature of myeloproliferative disorders but may also result from various conditions including chronic iron deficiency, hemorrhage, chronic inflammation and splenectomy. We report two cases of secondary thrombocytosis caused by isolated and congenital asplenia, mimicking essential thrombocythemia. These two adult cases of spleen agenesis were unexpected. We conclude th...

AIM To investigate possible abnormalities of serum potassium and calcium levels in patients with essential thrombocythaemia and significant thrombocytosis. METHODS 24 cases of essential thrombocythaemia with significant thrombocytosis (platelet count > 700 x 10(9)/litre) had serum potassium and calcium estimations performed at the time of maximum thrombocytosis before treatment, and at the ti...

Thrombocytosis is a frequent finding in hemograms obtained from hospitalized and ambulatory children due to the widespread use of automated blood cell counters. Pediatricians are commonly puzzled in cases of thrombocytosis to determine the underlying cause and the need for therapy. The purpose of this review is to assist the general pediatrician into dealing with this common hematological findi...

BACKGROUND AND PURPOSE Depending on the severity of the illness, thrombocytosis is found in about 60% to 70% of patients with Henoch-Schönlein purpura (HSP). Whether thrombocytosis is the result of an inflammatory reaction mediated by thrombopoietin (TPO) or other inflammatory cytokines such as interleukin (IL)-6 remains unknown. METHODS Thirty two patients who met the diagnostic criteria for...

Thrombocytosis may occur in association with autoimmune, collagen, and malignant diseases (Levin and Conley, 1964; Bean, 1965; Selroos, 1972; Davis and Mendez Ross, 1973). In rheumatoid arthritis a positive correlation has been found between the platelet count and disease activity (Bean, 1965; Selroos, 1972; Hryszko et al., 1975; Hemandez, 1975; Hutchinson et al., 1976). Thrombosis is infrequen...

In both children and adults, thrombocytosis is usually defined as a platelet count of more than 450 10/ L. As there are many primary and secondary causes, as well as false or “spurious” conditions mimicking thrombocytosis, establishing the cause requires considering clinical features and hematologic parameters. Pediatric primary thrombocytosis is very rare, but reactive thrombocytosis (RT) can ...

Systemic lupus is an autoimmune disease of worldwide distribution. The disease is characterized clinically by multisystem manifestations. Haematological manifestations are diverse. Thrombocytosis has rarely been reported in association with SLE and may occur as a result of active disease or reactive due to underlying inflammatory process. Our patient was a 14 years old female who was diagnosed ...

essential thrombocythemia is a rare myeloproliferative disorder in pediatrics. this myeloproliferative disorder is charactherized by thrombocytosis and hyperplasia of megakaryocytes in the bone marrow. other cell lines are not involved.jak2v617fmutations has been identified in approximately half the patients with this disorder. we describe a 12-year-old boy with essential throbocythemia. the pa...

In order to determine the prognostic significance of thrombocytosis in idiopathic sideroblastic anemia, the clinical courses of 17 patients were reviewed. Six patients (36%) had thrombocytosis, and none developed acute leukemia. Nine patients (53%) had normal platelet counts, and one developed acute leukemia. Two patients (12%) were thrombocytopenic, and one died of acute leukemia. There was li...