نتایج جستجو برای: thrombocythemia
تعداد نتایج: 1972 فیلتر نتایج به سال:
BACKGROUND Fifty to sixty percent of patients with essential thrombocythemia harbor the JAK2(V617F) mutation. The impact of this mutation on clinical phenotype is still debated. The aim of this study was to evaluate possible correlations between JAK2(V617F) mutant allele burden and both clinical presentation and hematologic abnormalities in essential thrombocythemia patients. DESIGN AND METHO...
Essential thrombocythemia is a myeloproliferative disorder characterized by frequent bleeding and thrombotic complications. On a molecular level, two abnormalities of platelet thrombospondin have been identified: abnormal glycosylation of the intact 185,000-dalton chain has been detected and a shortened form of the thrombospondin chain is present. We have used two monoclonal antibodies and Lens...
BACKGROUND AND OBJECTIVES Patients with high-risk essential thrombocythemia require cytoreductive therapy in order to normalize the elevated platelet counts. We evaluated the efficacy and toxicity of pegylated interferon in high-risk essential thrombocythemia in a phase II trial. DESIGN AND METHODS Thirty-six patients with high-risk essential thrombocythemia (median age 54 years; range, 24-72...
BACKGROUND The detection of molecular and cytogenetic alterations is important for the diagnosis, prognosis and classification of myeloproliferative neoplasms. OBJECTIVES THE AIM OF THIS STUDY WAS TO DETECT THE FOLLOWING MUTATIONS: JAK2 V617F, JAK2 exon 12 and MPL W515K/L, besides chromosomal abnormalities. Furthermore, molecular and cytogenetic alterations were correlated with the leukocyte ...
Background Thrombocytosis is defined as an increase in the number of circulating platelets than the normal value of between 150,000 and 250,000 platelets/uL. The limit beyond which the state of platelets is usually marked in platelets is defined as 400,000/uL. Trombocytosis are divided into primary or autonomous, in the course of myeloproliferative disorders (essential thrombocythemia, polycyth...
Satoh A, et al. Familial essential thrombocythemia associated with a dominant-positive activating mutation of the MPL gene, which encodes for the receptor for thrombopoi-etin. Identification of an acquired JAK2 mutation in poly-cythemia vera. Lacout C, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Huntly BJ, et al. Activating mutation in the ...
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