When developing an intelligent tutoring system, it is necessary to have a significant number of highly varied problems that adapt to a student’s individual learning style. In developing an intelligent tutor for logic proof construction, selecting problems for individual students that effectively aid their progress can be difficult, since logic proofs require knowledge of a number of concepts an...

Membrane fusion induced by enveloped viruses proceeds through the actions of viral fusion proteins. Once activated, viral fusion proteins undergo large protein conformational changes to execute membrane fusion. Fusion is thought to proceed through a "hemifusion" intermediate in which the outer membrane leaflets of target and viral membranes mix (lipid mixing) prior to fusion pore formation, enl...

OBJECTIVE We aimed to assess whether cognitive processes change over time in patients with obsessive-compulsive disorder (OCD) receiving selective serotonin reuptake inhibitors without cognitive behavioral therapy and to investigate the factors associated with probable cognitive changes. METHODS During the 16 weeks of the study, 55 patients who met the Diagnostic and Statistical Manual of Men...

Both thought-action fusion (TAF: i.e., a cognitive bias implying an inflated sense of responsibility for one's own thoughts) and thought suppression have been claimed to contribute to the development of obsession-like intrusions. Therefore, it seems plausible that conjunction of these phenomena results in highly intense intrusions. However, possible interactions between TAF and thought suppress...

Linguistic combinations are referred to as a chain of words that associate with one another and form a semantic phrases, such as adjectival and noun. Innovation in this field is one of the main tasks of creative poetry. Shams's sonnets are of the prominent works of Persian literature and their composition is characterized by its stylistic features. In order to express his sublime and mystical t...

Formation of a fusion pore between a vesicle and its target membrane is thought to involve the so-called SNARE protein complex. However, there is no mechanistic model explaining how the fusion pore is opened by conformational changes in the SNARE complex. It has been suggested that C-terminal zipping triggers fusion pore opening. A SNAP-25 mutant named SNAP-25Delta9 (lacking the last nine C-ter...