The effect of hemin on the differentiation program of murine erythroleukemia (MEL) cells has been investigated. While hemin treatment does induce increased levels of globin mRNA and hemoglobin, it fails to lead to other biochemical changes associated with MEL cell differentiation induced by DMSO and thioguanine. These include increased levels of the nuclear protein IP25 and of the enzyme cytidi...

The conducting polymers (CPs) are the important materials due to their large surface area, high thermal stability, good conductivity, easy shape, process and properties can be tuned by modifying structures or processing. Few have emerged as potential candidate for determination of a few anti-cancer drugs. In present study, sensing ability Poly-pyrrole (poly-py) has been investigated with withou...

Inhibition of HIV-1 reverse transcriptase (RT) and HIV protease are effective mechanisms for anti-retroviral agents, and the combined use of mechanistically different medications has markedly improved the treatment of HIV infected patients. The active metabolite of mercaptopurine and thioguanine (TG), deoxythioguanosine triphosphate, was shown to be incorporated into DNA by the polymerase funct...

We have examined the ability of SV40 to induce changes in drug or temperature resistance in mouse, hamster, and mouse-human hybrid cells. SV40 induced a substantial increase of cells resistant to 5-bromodeoxyuridine + trifluorothymidine in Balb/c 3T3 cells and induced an increase of hybrid cells resistant to 6-thioguanine. SV40 was found to be nonmutagenic or weakly mutagenic in other test syst...

When Ca-755 tumors of various sizes were treated with three doses of C14-labeled 6-thioguanine (10 mg/kg at 24-hour intervals) the specific activities of their deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) at the end of the treatment were independent of the starting size of the tumor. During the subsequent rapid tumor regression the specific activity of DNA and RNA decreased linearly w...