the present study aimed at investigating the beneficial effects of co-administering granulocyte colony–stimulating factor (g-csf) and stem cell factor (scf) in a model of chronic liver injury induced by thioacetamide (taa). biochemical and histopathology- cal examinations were performed on serum and liver specimens. at the end of the treatment period, the rats were anesthetized with ether, seru...

Liver cirrhosis can disturb circadian rhythms, decreasing patient quality of life. Changes in metabolic products in cirrhosis are poorly understood. We evaluated changes in liver metabolism products using a thioacetamide-induced mouse model of liver cirrhosis exhibiting circadian rhythm disturbance. Principal component analysis indicated that the circular progression found in the control group ...

Experiments were designed to establish the hepatoprotective activity of Plumbago indica (PLBM) methanolic root extracts at different doses (100 and 200 mg/kg bw) against thioacetamide-induced liver damage in albino Wistar rats. Hepatotoxicity was assessed by evaluating the activity of liver-function marker enzymes such as aspartate transaminase, alanine transaminase, alkaline phosphatase and la...

Male rats of the Sherman strain were fed for 2 weeks a diet ofgrohnd purina rat chow containing 0.04 per cent thioacetamide. Animals were injected intraperitoneally with tritiated cytidine, 200#c/100 gm body weight, and sacrificed in pairs, a control and a thioacetamidetreated rat, at prescribed intervals. Liver tissues were preserved with the freeze-substitution method and postfixed in anhydro...

Male rats of the Sherman strain were fed for 2 weeks a diet ofgrohnd purina rat chow containing 0.04 per cent thioacetamide. Animals were injected intraperitoneally with tritiated cytidine, 200#c/100 gm body weight, and sacrificed in pairs, a control and a thioacetamidetreated rat, at prescribed intervals. Liver tissues were preserved with the freeze-substitution method and postfixed in anhydro...

Oxidative stress due to iron deposition in hepatocytes or Kupffer cells contributes to the initiation and perpetuation of liver injury. The aim of this study was to clarify the association between dietary iron and liver injuries in rats. Liver injury was initiated by the administration of thioacetamide or ligation of the common bile duct in rats fed a control diet (CD) or iron-deficient diet (I...

The male reproductive system is vulnerable to oxidative stress, which linked several disorders. Silibinin, a natural polyphenolic flavonoid, possesses antioxidant, anti-inflammation and anticancer properties. Considering silibinin's wide range of biological metabolic roles (silibinin) plays, the current study was conducted evaluate biochemical, histological, immunohistochemical morphometric cha...

We synthesized single-phase CoS2 on a large scale by adding graphene oxide of sufficient quantity via the hydrothermal method using cobalt acetate and thioacetamide as precursors; this produced the hybrid of CoS2 with reduced graphene oxide which exhibited high electrocatalytic activity in the hydrogen evolution reaction.

BACKGROUND The liver plays an essential role in the body by regulating several important metabolic functions. Liver injury is associated with the distortion of these functions causing many health problems. Pharmaceutical drugs treat liver disorders but cause further damage to it. Hence, herbal drugs are used worldwide and are becoming increasingly popular. METHODS The hepatoprotective activit...