an efficient synthesis of methyl 2-[2-(alkylimino)-4-oxo-3-phenyl-1,3-thiazolan-5-yliden]acetate derivatives via simple three-component reaction and one-pot reactions between isoquinoline, dimethyl acetylenedicarboxylate and n-phenylthiourea under solvent-free conditions without using any additional catalyst, is described. the mild reaction conditions and good yields and exhibit the synthetic a...

In recent years, the studies of RNA and its use for development based vaccines have increased drastically. Although cyanine dyes are commonly used probes studying nucleic acids, in a wide range applications, there is still growing need better brighter dyes. To meet this demand, we systematically studied structure SYBR green-related to gain deeper understanding their interactions with biomolecul...