Somatic mutations or loss of expression of tumor suppressor VHL happen in the vast majority of clear cell Renal Cell Carcinoma, and it's causal for kidney cancer development. Without VHL, constitutively active transcription factor HIF is strongly oncogenic and is essential for tumor growth. However, the contribution of individual HIF-responsive genes to tumor growth is not well understood. In t...

Oc tober 20 07 How brain processes translate to consciousness is one of the greatest unsolved questions in science. Although the scientific method can delineate events immediately after the big bang and uncover the biochemical nuts and bolts of the brain, it has utterly failed to satisfactorily explain how subjective experience is created. As neuroscientists, both of us have made it our life’s ...

INTRODUCTION This article focuses on the first step of providing computer and information system security — developing and implementing an effective security awareness program. One might wonder why security awareness is not considered the same as training. The simple answer: because the desired outcome of each is different. The goal of a security awareness program is to heighten the importance ...