BACKGROUND There is increasing evidence that sex differences may influence responses after thermal injury and affect clinical outcomes. The objective of this study was to evaluate the relationships between sex, thermal injury, body size, and inpatient mortality in burn patients. METHODS Medical records of adults with >20% total body surface area (TBSA) burn injury admitted to two American Bur...

BACKGROUND The use of propranolol has been proposed to reduce the hypermetabolic response of patients with burn injuries. OBJECTIVES To review the studies published up to December 2013 on the effects of propranolol in burn patients. METHODS A PubMed search was conducted using the terms "burns", "thermal injury", "beta-blocker" and "propranolol", with the filters "human" and "English" and "S...

To evaluate the effect of phenytoin on burn wounds and to compare the effect of the combination of topical phenytoin preparation in dexamethasone treated burn wounds in rats, partial thickness thermal burn wounds were inflicted upon five groups of six rats each. Group I was assigned as control, Group II received the standard silver sulphadiazine, Group III was given topical phenytoin and Group ...

The purpose of the present study was to determine whether burn injury decreases myocardial protein synthesis and potential contributing mechanisms for this impairment. To address this aim, thermal injury was produced by a 40% total body surface area full-thickness scald burn in anesthetized rats, and the animals were studied 24 h late. Burn decreased the in vivo-determined rate of myocardial pr...

Thermal trauma is associated with cardiac myocyte apoptosis in vivo. To determine whether cardiac myocyte apoptosis could be secondary to burn-induced cytokines or inflammatory mediators, we investigated the effects of tumor necrosis factor-alpha (TNF-alpha) and burn plasma on a murine cardiac myocyte cell line and primary culture myocytes. HL-1 cells were exposed to plasma isolated from burned...

4,547 burn patients from 1983-1993 were reviewed by analysing the general data, mortality, and the causes of the death, and the mortality of 606 burn patients in different periods from 1958 to 1993. The purpose was to present some statistical and epidemiological data. The results showed: The incidence of burn injury in children, whose ages were less than 5 years, reached 36.2%, and the causes o...

The emergency clinician is frequently called upon to treat burn wounds secondary to thermal, chemical, electrical, or radiation injury. Most burn wounds seen in veterinary medicine are relatively minor, possibly because animals with severe burns and smoke inhalation are less likely to be rescued from the scene of a house fire. However, life threatening burns and inhalation injury are being seen...

Traditionally, burn wounds are classified according to three different “degrees”, indicating the depth of the cellular destruction induced by the thermal energy transfer. Although this classification has the advantage of being relatively simple (and largely based on macroscopic indicators such as blisters, exudate, colour and sensitivity), it does not permit in all cases to make an accurate pre...

Temperature evolution and skin burn process in biological samples exposed to laser radiation are investigated in this communication. A one-dimensional multi-layered model is presented and transient temperature is numerically estimated using a finite difference method. A damage function corresponding to the extent of burn injury and using the Arrhenius assumptions is proposed. Two experimental b...

INTRODUCTION Development of secondary hyperalgesia following a cutaneous injury is a centrally mediated, robust phenomenon. The pathophysiological role of endogenous opioid signalling to the development of hyperalgesia is unclear. Recent animal studies, carried out after the resolution of inflammatory pain, have demonstrated reinstatement of tactile hypersensitivity following administration of ...