Tumor microenvironments are the result of cellular alterations in cancer that support unrestricted growth and proliferation further modifications cell behavior, which critical for tumor progression. Angiogenesis therapeutic resistance known to be modulated by hypoxia other microenvironments, such as acidic stress, both core features glioblastoma microenvironment. Hypoxia has also been shown pro...

Tumor suppressor gene p53 and its aggregate have been found to be involved in many angiogenesis-related pathways. We explored the possible aggregation formation mechanisms commonly occur after ischemic stroke, such as hypoxia presence of reactive oxygen species (ROS). The angiogenic pathways involving mainly nucleus or cytoplasm, with one exception that occurs mitochondria. Considering high mit...

Several lines of evidence have revealed that the angiogenic response to ischemic injury declines with age, which might account for the increased morbidity and mortality of cardiovascular disease (CVD) among the elderly. While impairment of angiogenesis with aging leads to delayed wound healing or exacerbation of atherosclerotic ischemic diseases, it also inhibits the progression of cancer. Age-...

AGGF1 is an angiogenic factor with therapeutic potential to treat coronary artery disease (CAD) and myocardial infarction (MI). However, the underlying mechanism for AGGF1-mediated therapeutic angiogenesis is unknown. Here, we show for the first time that AGGF1 activates autophagy, a housekeeping catabolic cellular process, in endothelial cells (ECs), HL1, H9C2, and vascular smooth muscle cells...

Abstract Colorectal cancer (CRC) is one of the most common malignancies worldwide. Circular RNAs (circRNAs) are involved in pathological processes, especially development cancers, but roles circRNAs CRC largely unknown. In this study, we investigated role and underlying mechanisms Circ_0030998 cell proliferation angiogenesis. We found that was upregulated tissues cells, its upregulation related...

Extramedullary disease (EMD) of multiple myeloma (MM) can present as paraskeletal (paraosseous) plasmocytoma (PP) that arise from skeletal focal lesions or extramedullary plasmacytomas (EMP) derive hematogenous spread. The pathogenetic mechanisms distinguish classical MM, PP, and EMP are still insufficiently known, the therapies would be effective in EMD. aim this study was to evaluate immunohi...