Objective: Aim was to evaluate the sensitivity and specificity of Mentzer index in differentiating beta thalassemia minor from anemia Iron deficiency. Materials Methods: A cross-sectional study conducted Hematology unit Hayatabad Medical Complex .Sampling done non-consecutively. total 860 cases with value Hemoglobin less than 11 Gm/DL were counted. In all selected full blood count checked Index...

In India the incidence of beta thalassemia trait in general population is about 3%. There are a number of communities in India such as Sindhi, Lohana, Khoja, Bhanushali, Punjabi, Jain, Muslim and Bengali in whom the incidence of beta thalassemia trait ranges between 8% to 15%. The high incidence can be attributed to consaguinity and endogamy practised in these communities. It is evident that if...

β Thalassemia Trait(BTT) produces mild ineffective erythropoiesis and associated increased iron absorption from the gut. Based on these reasons it had been suggested that BTT confers an advantage in maintaining iron balance, in which case prevalence of iron deficiency should be lower in those with the trait. This Study was carried out to determine the frequency of coexistence of iron deficiency...

The diagnostic value of common hematology tests in differentiating between thalassemia trait and iron-deficiency anemia (IDA) was assessed. Serum iron concentration was included in a second stage of the diagnostic model and its predictive contribution was determined. After applying discriminant analysis to the data, minimization of Wilks's lambda (lambda) criterion was used to select the best p...

In Yemen, the prevalence of sickle cell trait and β-thalassemia trait are high. The aim of this premarital program is to identify sickle cell and thalassemia carrier couples in Yemen before completing marriages proposal, in order to prevent affected birth. This can be achieved by applying a low-cost premarital screening program using simple blood tests compatible with the limited health resourc...

Synthesis of globin chains in bone the heterozygotes, there was a signifimarrow and peipheral blood samples cant defect in beta synthesis in the from a black family with mild beta peripheral blood of white subjects, thalassemia was compared with simiwhile in two of three black patients the lar studies in white people. Blood and P/ ratio was in the normal range. Albone marrow were incubated with...

Hemoglobin E heterozygotes (Hb AE) are asymptomatic and homozygotes (Hb EE) have a mild microcytic anemia . However, we had a 2 year old female child presenting with moderate pallor necessitating blood transfusions at 6 months to 1 year interval starting from eight months of age. Thorough clinical examination and investigative work-up revealed Hb E trait with Gaucher’s disease. To the best of o...

Background The protective effect of α-thalassemia, a common hematological disorder in Southeast Asia, against Plasmodium falciparum malaria has been well established. However, there is much less understanding of the effect of α-thalassemia against P. vivax. Here, we aimed to investigate the proportion of α-thalassemia including the impact of α-thalassemia and HbE on the parasitemia of P. vivax ...

100 patients with beta-thalassemia trait, comprised of 55 men and 45 women, participated in a study to measure serum lipoproteins. the results were compared with the data obtained from 100 control subjects of the same age and sex. a significantly lower level of mean serum total cholesterol and ldl cholesterol, and a much higher level of hdl cholesterol were obtained in beta-thalassemia trait as...

Thalassemia is defined as a condition in which reduced rate of synthesis of one or more of the globin chains leads to defective haemoglobin production. Of the two major types, in alphathalassemia, occhain synthesis is absent or diminished and in beta-thalassemia, B-chain synthesis is absent or diminished. In B-thalassemia, anaemia occurs due to reduced B globulin, which in turn reduces HbA resu...