Objective: Interleukin (IL)-22 is a cytokine that is involved in the modulation of tissue remodeling during inflammation. Different types of T cells secrete IL-22. IL-6 and tumor necrosis factor α (TNF-α) induce Th22 cells to produce IL-22, particularly in the skin, whereas γδ T cells produce IL-22 in response to IL-23, particularly in the lung. IL-22 is known to be expressed in many chronic in...

INTRODUCTION The aim of this study was to characterize interleukin 17 (IL-17) and interleukin 22 (IL-22) producing cells in peripheral blood (PB), skin, synovial fluid (SF) and synovial tissue (ST) in patients with psoriasis (Ps) and psoriatic arthritis (PsA). METHODS Flow cytometry was used to enumerate cells making IL-22 and IL-17, in skin and/or SF and PB from 11 patients with Ps and 12 pa...