نتایج جستجو برای: tgf β antagonist
تعداد نتایج: 249600 فیلتر نتایج به سال:
TGF-β is required for both Foxp3(+) regulatory T cell (Treg) and Th17 commitment. Plasmacytoid DCs (pDC) have been shown to participate to both Treg and Th17 commitment as well. However, few studies have evaluated the direct effect of TGF-β on pDC, and to our knowledge, no study has assessed the capacity of TGF-β-exposed pDC to polarize naive CD4(+) T cells. In this paper, we show that TGF-β-tr...
Transforming growth factor β (TGF-β) is involved in cellular processes including growth, differentiation, apoptosis, migration, and homeostasis. Generally, TGF-β is the inhibitor of cell cycle progression and plays a role in enhancing the antagonistic effects of many growth factors. Unlike the antiproliferative effect of TGF-β, E2, an endogeneous estrogen, is stimulating cell proliferation in t...
Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary pressure and carries a very poor prognosis. Understanding of PAH pathogenesis needed to support the development new therapeutic strategies. Transforming growth factor β (TGF-β) drives vascular remodeling increases resistance regulating differentiation proliferation smooth muscle cells (SMCs). Also, sphing...
Loeys-Dietz syndrome (LDS) is a connective tissue disorder that is characterized by skeletal abnormalities, craniofacial malformations, and a high predisposition for aortic aneurysm. In this issue of the JCI, Gallo et al. developed transgenic mouse strains harboring missense mutations in the genes encoding type I or II TGF-β receptors. These mice exhibited several LDS-associated phenotypes. Des...
مقدمه: اثرات محافظتی فاکتور رشد tgf-β در انواع مختلفی از بیماری های خودایمنی به خصوص بیماری هایی که در آنها اندام خاصی درگیر می شود مورد بررسی قرارگرفته که بیماری دیابت نوع 1 از آن جمله است. tgf-β همچنین با تحریک تولید سایتوکاین هایی از th17، به عنوان یک واسطه پیش التهابی مطرح است. هدف از انجام این مطالعه بررسی و مقایسه تفاوت در میزان بیان ژن tgf-β در سلول های تک هسته ای خون محیطی تحریک نشده (p...
We determined whether human lung fibroblasts (HLFs) might release mediators that are responsible for monocyte chemokinetic activity (MCA) constitutively. HLF supernatant fluids showed MCA in a time-dependent manner ( P < 0.001). Checkerboard analysis of 24- and 72-h supernatant fluids showed that the activity was chemokinetic. Partial characterization of 24- and 72-h supernatant fluids revealed...
The nature of host-virus interactions in hepatitis B virus infection is incompletely understood. Since soluble factors, e.g., cytokines and metals, may exacerbate liver injury in chronic hepatitis, we considered that defining the effects of receptor-mediated signaling upon viral replication will be significant. Consequently, we studied effects of iron or TGF-β-induced TGF-β/BMP signaling in the...
BACKGROUNDS The Loeys-Dietz syndrome (LDS) is an inherited connective tissue disorder caused by mutations in the transforming growth factor β (TGF-β) receptors TGFBR1 or TGFBR2. Most patients with LDS develop severe aortic aneurysms resulting in early need of surgical intervention. In order to gain further insight into the pathophysiology of the disorder, we investigated circulating outgrowth e...
Background: Transforming growth factor-β (TGF-β) in addition to the C-terminal region can phosphorylate receptor-regulated Smads (R-Smads) in their linker region. The aim of the present study was to evaluate the role of signaling mediators such as NAD(P)H oxidases (reactive oxygen species [ROS] generators), ROS, and ROS-sensitive p38 mitogen-activated protein kinase (p38MAPK) in this signaling ...
BACKGROUND/AIMS TGF-β plays a key role in the progression of various tumors. The main objective of our study was to investigate whether TGF-β is able to regulate N-nitrosodiethylamine (DEN)-induced hepatocellular carcinoma (HCC) progression in a mouse model by inducing Treg cell polarization. METHODS HCC progression, TGF-β and Foxp3 expression levels, serum TGF-β, IL10 and GP73 levels as well...
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