Dolutegravir (DTG) is an HIV integrase inhibitor that was recently approved for therapy by the Food and Drug Administration in the United States. When used as part of first-line therapy, DTG is the only HIV drug that has not selected for resistance mutations in the clinic. We believe that this is due to the long binding time of DTG to the integrase enzyme as well as greatly diminished replicati...

The effect of high temperature on engineering properties rocks has recently become an important topic for geotechnical applications due to the development in geothermal energy extraction, underground coal gasification, disposal nuclear waste and deep mining applications. This study aims investigate four heated at temperatures identify corresponding mineralogical changes. Two types sandstone (Be...

Abstract Synthesis and characterization of sodium alginate from Sargassum aquifolium dan cinereum have been successfully performed. S. were collected the Dompu Islands, West Nusa Tenggara, Indonesia. Extraction was performed by acid pathway, due to cell disruption addition Na 2 CO 3 for extraction. The HCl convert into alginate, then transformed using NaOH. NaOCl IPA used purification. Physicoc...

Dolutegravir (DTG; S/GSK1349572) is a potent HIV-1 integrase inhibitor with a distinct resistance profile and a once-daily dose regimen that does not require pharmacokinetic boosting. This work investigated the in vitro drug transport and metabolism of DTG and assessed the potential for clinical drug-drug interactions. DTG is a substrate for the efflux transporters P-glycoprotein (Pgp) and huma...

acanthophyllum laxiusculum is one of the most widely distributed species of the genus in iran that flourishes in steppe and mountainous regions of the country. in the present study, water-soluble content of a. laxiusculum roots was extracted by boiling water and further successively purified partially by a defined solvent system. surface tension measurements revealed the ability of plant extrac...

DTG are designed to share some of the advantages of TAG while overcoming some of its limitations. DTG involve two composition operations called subsertion and sisteradjunction. The most distinctive feature of DTG is that, unlike TAG, there is complete uniformity in the way that the two DTG operations relate lexical items: subsertion always corresponds to complementation and sister-adjunction to...

INTRODUCTION Dolutegravir (DTG) 50 mg once daily was superior to darunavir/ritonavir (DRV/r) 800 mg/100 mg once daily through Week 48, with 90% vs. 83% of participants achieving HIV RNA 50 c/mL (p=0.025) [1]. We present data through Week 96. MATERIAL AND METHODS FLAMINGO is a multicentre, randomized, open-label, Phase IIIb non-inferiority study, in which HIV-1-positive ART-naïve adults with H...

Acanthophyllum laxiusculum is one of the most widely distributed species of the genus in Iran that flourishes in steppe and mountainous regions of the country. In the present study, water-soluble content of A. laxiusculum roots was extracted by boiling water and further successively purified partially by a defined solvent system. Surface tension measurements revealed the ability of plant extrac...

Fushun oil shale semi-coke and its extracted bitumen were prepared for analyzing their pyrolysis characteristics by TG–DTG, TG–FTIR, Py–GC/MS. Semi-coke was the residue of pyrolyzed to 450 °C, organic matter from with [Bmim]Cl/NMP mixed solvents. Gaussian fitting method used analyze proportions bond cleavage reactions occured during 700 °C at a heating rate 20 °C/min. Results showed that 3–4 ki...