1,1,2-Trichloroethylene (TCE), a volatile organic contaminant (VOC) of drinking water in the Unites States, is frequently present in trace amounts. TCE is currently classified by the International Agency for Research on Cancer and the U.S. Environmental Protection Agency as a probable human carcinogen, because it produces tumors in some organs of certain strains of mice or rats in chronic, high...

Trichloroethylene (TCE) has been widely used as a degreasing agent in many manufacturing industries. Recently, the International Agency for Research on Cancer presented "sufficient evidence" for the causal relationship between TCE and kidney cancer. The aim of this study was to review the epidemiologic evidences regarding the relationship between TCE exposure and kidney cancer in Korean work en...

We have shown previously that chronic (32 weeks) exposure to occupationally relevant concentrations of the environmental pollutant trichloroethylene (TCE) induced autoimmune hepatitis (AIH) in autoimmune-prone MRL+/+ mice. In real-life, individuals are never exposed to only one chemical such as TCE. However, very little is known about the effects of chemical mixtures on the immune system. The c...

A large body of epidemiologic evidence exists for exploring causal associations between cancer and trichloroethylene (TCE) exposure. The U.S. Environmental Protection Agency 2001 draft TCE health risk assessment concluded that epidemiologic studies, on the whole, support associations between TCE exposure and excess risk of kidney cancer, liver cancer, and lymphomas, and, to a lesser extent, cer...

Experiments were performed in a laboratory chamber to investigate the influence of alfalfa plants on the fate and transport of trichloroethylene (TCE) fed at 200 μl/l concentration in the entering ground water. Concentrations of TCE in the aqueous and gas phases were regularly monitored in the chamber. Evapotranspirational fluxes of TCE were also reported from the soil to the headspace of the c...

We estimated the distribution of chlorinated aliphatic hydrocarbons (CAHs) from groundwater samples collected along three transects in a sand aquifer. Trichloroethylene (TCE) leaked and contaminated the aquifer probably more than a decade before we collected the measurements. The data show significant concentrations of TCE, cis-1,2dichloroethylene (c-DCE), vinyl chloride (VC), and ethene. We at...

Laboratory incubation experiments were carried out to assess the potential of methanotrophic culture for degrading TCE. Measurements of the growth rate and TCE degradation showed that the methanotrophs not only grew in presence of TCE but also degraded TCE. The rate of TCE degradation was found to be 0.19 ppm h(-1). The reverse transcriptase-PCR test was conducted to quantify expression of pmoA...

Tidal volume (VT), minute ventilation (VE), the duration of inspiratats anaesthetized with 0.7%, 1% and 1.5% (inspired) trichloroethylene (TCE). The tracheal cannula was occluded at intervals at the start of inspiration and the tracheal pressure was measured to assess the force of contraction of the respiratory muscles. Anaesthesia with TCE 0.7% was associated with an increase in VE, a reductio...

Current evaluation Conclusion from the previous Monograph: Trichloroethylene (TCE) is probably carcinogenic to humans (Group 2A) based on limited evidence in humans for the carcinogenicity of TCE and sufficient evidence in experimental animals for the carcinogenicity of TCE. In making the overall evaluation, the Working Group considered the following evidence: (i) although the hypothesis linkin...

Epidemiological studies suggest that trichloroethylene (TCE) exposure may be associated with renal cancer. The biological mechanisms involved are not exactly known although nephrotoxicity is believed to play a role. Studies on TCE nephrotoxicity among humans, however, have been largely inconsistent. We studied kidney toxicity in Chinese factory workers exposed to TCE using novel sensitive nephr...