Pregnant CD-1 mice were given 32 mg/kg of 3,4,3',4'-tetrachlorobiphenyl (TCB) or corn oil vehicle, by gavage, on days 10--16 of gestation. At 1 year of age, the offspring were tested for spontaneous motor activity; the mice were then killed and dopamine (DA) levels and specific DA receptor binding were measured in the corpus striatum. Mice exposed to TCB in utero had elevated levels of motor ac...

This paper proposes a novel feature for conditional random field (CRF) model in Chinese word segmentation system. The system uses a conditional random field as machine learning model with one simple feature called term contributed boundaries (TCB) in addition to the “BIEO” character-based label scheme. TCB can be extracted from unlabeled corpora automatically, and segmentation variations of dif...

This chapter will focus on techniques that have been developed to measure transcutaneous bilirubin (TcB). The first electronic TcB device proved to be useful when used as a screening method for identifying newborns who needed a serum bilirubin determination. Newer TcB devices can be used not only as screening tools but also as reliable substitutes for serum bilirubin measurements. The Chromatic...

Background: The readmission rate for neonatal jaundice has been increased in recent years. This has been attributed to shorter length of postpartum hospital stays without comprehensive follow-up. The purpose of this study was to determine the diagnostic value of pre-discharge transcutaneous bilirubin (TcB) levels for prediction of subsequent hyperbilirubinemia in healthy term neonates. Metho...

Objectives: To study the reliability of a transcutaneous bilirubinometer (Bilicheck) to determine bilirubin levels in neonates consulting for jaundice in a Paediatric Emergency Department (ED), and to evaluate its usefulness as a screening method. Methods: Prospective observational study realized between June of 2005 and December of 2005 in neonates consulting at a paediatric emergency departme...

BACKGROUND Hyperbilirubinemia can lead to potentially irreversible bilirubin-induced neurotoxicity. Transcutaneous bilirubin (TcB) determination has become a valuable aid in non invasive screening of neonatal jaundice.The aim of this study is to compare the performance of three most widespread transcutaneous bilirubinometers on a multiracial population of term and late pre-term neonates. METH...

In Salmonella enterica, tricarballylate (Tcb) catabolism requires function of TcuB, a membrane-bound protein that contains [4Fe-4S] clusters and heme. TcuB transfers electrons from reduced flavin adenine dinucleotide in the Tcb dehydrogenase (TcuA) to electron acceptors in the membrane. We recently showed that functions needed to assemble [Fe-S] clusters (i.e., the iscRSUA-hscBA-fdx operon) com...

Microsomal cytochrome P-450 1A (CYP1A) in a vertebrate model (the teleost fish scup) is inactivated by the aryl hydrocarbon receptor agonist 3,39,4,49-tetrachlorobiphenyl (TCB). Here, the mechanism of CYP1A inactivation and its relationship to reactive oxygen species (ROS) formation were examined by using liver microsomes from scup and rat and expressed human CYP1As. In vitro inactivation of sc...

Introduction The biotransformation of polychlorinated biphenyls, world-wide environmental pollutants, is initiated mainly by an oxygenation of aromatic ring catalyzed by liver cyochrome P450(P450) [1]. A series of our studies using some tetrachlorobiphenyls (TCBs), major components of Kanechlor 400 caused Yusho poisoning in Japan in 1968, demonstrated that the hydroxylating ability of liver mic...

IT systems with advanced security requirements increasingly apply problem-specific security policies for describing, analyzing, and implementing security properties. Security policies are a vital part of a system’s trusted computing base (TCB). Hence, both correctness and tamper-proofness of a TCB’s implementation are essential for establishing, preserving, and guaranteeing a system’s security ...