In a recent study we detected marked differences in the antigenic profile of acral lentiginous melanoma (ALM) and nodular melanoma lesions. Furthermore, we showed that the human high molecular weight melanoma-associated antigen (HMW-MAA) is expressed with a significantly higher frequency in metastatic than in primary ALM lesions. Because of the potential role of HMW-MAA in the metastatic proces...

BACKGROUND AND STUDY AIMS Chronic liver disease (CLD) can cause hepatopulmonary syndrome (HPS), defined as triad of liver disease, hypoxemia, and intrapulmonary vascular dilation (IPVD). The aim of this study was to determine the evidence of IPVD in a cohort of pediatric patients with CLD pre- and post-liver transplantation (LT). MATERIAL AND METHODS All pediatric patients with CLD listed for...

The immunogenicity in patients with melanoma, in monkeys, and in rabbits of four human melanoma-associated antigens (MA A) defined by murine monoclonal antibodies was investigated. The latter included the high molecular weight MAA and the (M, 115,000,100,000, and 95,000150,000 MAA. To this end sera from patients with melanoma, from monkeys, and from rabbits immunized with cultured human melanom...

Considering the characteristics of Simulated Annealing Algorithm (SAA), based on the agents’ perception and retroaction to their surroundings, in this paper a new algorithm called Multi-agent Annealing Algorithm (MAA) is presented. And the global convergence of MAA is gotten. Finally, we make several numerical experiments to compare MAA with SAA and Genetic Algorithm (GA) by three classical tes...

Candida-associated denture stomatitis (CADS) is a significant clinical concern. We have demonstrated that urethane-based denture biomaterials with 10% methacrylic acid (MAA) could bind and then slowly release antifungal drug for months. Drugs on the resins could be repeatedly quenched/recharged, and in subsequent recharging, they could be changed/switched to more potent/effective ones. However,...

Malondialdehyde and acetaldehyde react together with proteins in a synergistic manner and form hybrid protein adducts, designated as MAA adducts. MAA-protein adducts are composed of two major products whose structures and mechanism of formation have been elucidated. MAA adduct formation, especially in the liver, has been demonstrated in vivo during ethanol consumption. These protein adducts are...

Understanding the behavior of airflow in a room is essential for building designers to provide the most efficient design of ventilation system, and having acceptable indoor air quality. This trend is the motive to solve the relationship between airflow parameters and thermal comfort. This paper investigates airflow characteristics, indoor air quality (IAQ), and the thermal comfort (TC) in a ven...

Malondialdehyde-acetaldehyde adducts (MAA) have been implicated in atherosclerosis. The purpose of this study was to investigate the role of MAA in atherosclerotic disease. Serum samples from controls (n = 82) and patients with; non-obstructive coronary artery disease (CAD), (n = 40), acute myocardial infarction (AMI) (n = 42), or coronary artery bypass graft (CABG) surgery due to obstructive m...

Leea indica is a medicinal plant used traditionally to cure cancer. In this study, the cytotoxic compounds of L. indica were isolated using bioassay-guided approach. Two cycloartane triterpenoid glycosides, mollic acid arabinoside (MAA) and mollic acid xyloside (MAX), were firstly isolated from L. indica. They inhibited the growth of Ca Ski cervical cancer cells with IC(50) of 19.21 μM (MAA) an...

This work describes methacrylic acid functionalized β-cyclodextrin (MAA-βCD) as a novel functional monomer in the preparation of molecular imprinted polymer (MIP MAA-βCD) for the selective removal of 2,4-dichlorophenol (2,4-DCP). The polymer was characterized using Fourier Transform Infrared (FTIR) spectroscopy, Brunauer-Emmett-Teller (BET) and Field Emission Scanning Electron Microscopy (FESEM...