The diagnosis of tuberculous meningitis (TBM) remains a complex issue because the most widely used conventional diagnostic tools, such as culture and PCR assay for cerebrospinal fluid (CSF) samples, are unable to rapidly detect Mycobacterium tuberculosis with sufficient sensitivity in the acute phase of TBM. Based on TaqMan PCR, we designed a novel technique consisting of an internally controll...

Tuberculous meningitis (TBM) is the most devastating form of tuberculosis. Both intracerebral and peripheral blood immune responses may be relevant to pathogenesis, diagnosis, and outcome. In this study, the relationship between pretreatment host response, disease phenotype, and outcome in Vietnamese adults with TBM was examined. Before treatment, peripheral blood IFN-gamma ELISPOT responses to...

Tensor-based morphometry (TBM) is an image analysis technique that measures brain structural differences, cross sectional differences or changes over time in repeat scans, from the gradients of deformation fields that align one image to another. TBM may be applied to cross-sectional MRI data for local volumetric comparisons, based on nonlinearly registering individual brain scans to a common an...

Tuberculosis (TB) which is caused by Mycobacterium tuberculosis infects primarily the lungs but it also affects other parts of the body. Tuberculous meningitis (TBM) is the most severe form of TB and has the highest mortality and morbidity rate compared to other forms of TB. It is common in young children and HIV-infected patients, but is also seen in adults. Despite anti-tuberculosis treatment...

INTRODUCTION Central nervous system tuberculosis is the most severe form of extrapulmonary TB and it is associated with a substantial morbidity and mortality. OBJECTIVES To describe the demographic profile, clinical features, laboratory and imaging results of a cohort of adult patients with TBM (Tuberculous meningitis). METHODS This study encompasses a prospective analysis of all adult case...

Since the first record of a colliery explosion in Belgium, nearly 300 years ago, significant improvements have been achieved in the prevention of explosions in mines. However, based on the past surface TBM project safety statistics, gas explosion hazards are not unique to coal mines but also occur in TBM projects with 48 explosion fatalities recorded worldwide calling for continued diligence an...

PURPOSE Late diagnosis and treatment lead to high mortality and poor prognosis in tuberculous meningitis (TbM). A rapid and accurate diagnosis is necessary for a good prognosis. Neuron-specific enolase (NSE) has been investigated as a biochemical marker of nervous tissue damage. In the present study, the usefulness of NSE was evaluated, and a cut-off value for the differential diagnosis of TbM ...

BACKGROUND Chronic neuropsychological sequelae may occur in patients with tuberculous meningitis (TBM). The impact of structural abnormalities on the clinical performance of patients with TBM is unknown. This study applied the Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra (DARTEL) voxel-based morphometry (VBM) to determine if gray matter deficits in TBM are associated ...

BACKGROUND Patterns of pulmonary function tests (PFTs) and flow-volume loops among patients with clinically important tracheobronchomalacia (TBM) are not well described. Small studies suggest 4 main flow-volume loop morphologies: low maximum forced expiratory flow, biphasic expiratory curve, flow oscillations, and notching. We studied common PFT and flow-volume loop patterns among the largest p...

Background: Evidence suggests that T cell-based interferon-γ release assays (IGRAs) may be useful for the diagnosis of tuberculosis. The present study aims to investigate the clinical significance of blood T-SPOT.TB assay, a commercially available IGRAs, in tuberculous meningitis (TBM) patients. Methods: Records of consecutive TBM and non-TBM meningitis patients admitted from July 2011 to March...