objective(s):alzheimer's disease (ad) is the most common age-related neurodegenerative disorder. one of the hallmarks of ad is an abnormal accumulation of fibril forms of tau protein which is known as a microtubule associated protein. in this regard, inhibition of tau aggregation has been documented to be a potent therapeutic approach in ad and tauopathies. unfortunately, the available syn...

objective(s):breast cancer is an important leading cause of death from cancer. stathmin and tau proteins are regulators of cell motility, and their overexpression is associated with the progression and bad prognosis of breast cancer. memantine, an n-methyl-d-aspartate (nmda) receptor antagonist, is the potential inhibitor of tau protein in neurons. this study determines the effect of memantine ...

tau is one of several types of microtubule-associated proteins (maps), responsible for the assembly and stability of microtubule networks that is present only in neurons and predominantly localized in axons which its functions are tightly regulated by phosphorylation. via as yet unknown mechanisms, tau becomes hyperphosphorylated and accompanies with neuronal degeneration, loss of synapses, abe...

We present an approximate treatment of the mixing between ${\ensuremath{\nu}}_{\ensuremath{\tau}}$ (${\overline{\ensuremath{\nu}}}_{\ensuremath{\tau}}$) and a sterile species ${\ensuremath{\nu}}_{s}$ (${\overline{\ensuremath{\nu}}}_{s}$) with vacuum mass-squared difference $\ensuremath{\sim}{10}^{2}--{10}^{3}\text{ }\text{ }{\mathrm{keV}}^{2}$ in protoneutron stars created core-collapse superno...

Background Previous studies have identified more than 20 genetic loci to be associated with AD risk. These reported do not account for all the estimated heritability nor report enough information on undelaying biological mechanism. Genome-wide association of endophenotypes new Alzheimer’s disease. To better understand pathology and identify variants implicated in much larger samples size is nee...

a topoframe, denoted by $l_{ tau}$,  is a pair $(l, tau)$ consisting of a frame $l$ and a subframe $ tau $ all of whose elements are complementary elements in$l$. in this paper, we define and study the notions of a$tau $-real-continuous function on a frame $l$ and the set of realcontinuous functions $mathcal{r}l_tau $ as an $f$-ring.we show that $mathcal{r}l_{ tau}$is actually a generalization ...

We present a unified framework to efficiently approximate solutions fractional diffusion problems of stationary and parabolic type. After discretization, we can take the point view that solution is obtained by matrix-vector product form f τ ( L ) b $$ {f}^{\boldsymbol{\tau}}(L)\mathbf{b} , where discretization matrix spatial operator, \mathbf{b} prescribed vector, {f}^{\boldsymbol{\tau}} parame...

Let $A$ be a Banach ternary algebra over a scalar field $Bbb R$ or $Bbb C$ and $X$ be a ternary Banach $A$--module. Let $sigma,tau$ and $xi$ be linear mappings on $A$, a linear mapping $D:(A,[~]_A)to (X,[~]_X)$ is called a Lie ternary $(sigma,tau,xi)$--derivation, if $$D([a,b,c])=[[D(a)bc]_X]_{(sigma,tau,xi)}-[[D(c)ba]_X]_{(sigma,tau,xi)}$$ for all $a,b,cin A$, where $[abc]_{(sigma,tau,xi)}=ata...

The tempered fractional diffusion equation could be recognized as the generalization of classic that truncation effects are included in bounded domains. This paper focuses on designing high order fully discrete local discontinuous Galerkin (LDG) method based generalized alternating numerical fluxes for equation. From a practical point view, flux which is different from purely has broader range ...

We explore the role of matter effect in evolution neutrino oscillation parameters presence lepton-flavor-conserving and lepton-flavor-violating neutral-current non-standard interactions (NSI) neutrino. derive simple approximate analytical expressions showing evolution/running mass-mixing with energy standard (SI) SI+NSI (considering both positive negative values real NSI parameters). observe th...