نتایج جستجو برای: targeting drug delivery
تعداد نتایج: 872120 فیلتر نتایج به سال:
This work shows the synthesis of a drug delivery system made casein nanoparticles able to host hydrophobic molecules and be functionalized with aptamers targeting epidermal growth factor receptor.
Recently a number of lipid based systems like lipospheres, liposomes, niosomes, ethosomes, and transferosomes have been developed. The purpose of this review article on colloidosome drug delivery was to compile the focus on the types, properties, fabrication techniques, characterization and stability of colloidosomes. This system also solves the problem of insolubility, instability, rapid degra...
We developed a novel self-targeted multi-drug co-delivery system based on rod-shaped 10-hydroxycamptothecin (CPT) nanoanticancer drug (CPT NRs) followed by a surface functionalization with self-targeting PEGylated lipid-conjugated methotrexate (MTX) pro-anticancer drug. The self-targeting effect and in vitro cell viability of the MTX-PEG-CPT NRs on HeLa cells were demonstrated by comparative ce...
Chemotherapy has been the main known treatment for cancer diseases. However, its achievement rate remains low, mainly because of the restricted accessibility of drugs to the tumor tissue, their painful toxicity, and development of multi-drug resistance. In recent years, either better understanding of tumor biology or development of the ever-growing field of nanotechnology has proposed new treat...
Combination of RGD cell adhesion peptide with GHK modulator synergistically improves targeting tumor cells. Amphiphilic peptides can be effectively displayed on liposomal surface for screening and drug delivery applications.
ethosomes are a novel and alternative drug delivery systems and currently the focus of many research activities. ethosomes are soft, flexible vesicles that are composed mainly of phospholipids, ethanol and water. ethosomes can provide better skin permeation than liposomes and deliver enhanced amounts of both small and large therapeutic agents through skin and targeting to deeper skin layers for...
Nanotechnology offers an alternative to conventional treatment options by enabling different drug delivery and controlled-release delivery strategies. Liposomes being especially biodegradable and in most cases essentially nontoxic offer a versatile platform for several different delivery approaches that can potentially enhance the delivery and targeting of therapies to tumors. Liposomes penetra...
A new microsphere consisting of inorganic mesoporous silica nanoparticles (MSNs) and organic alginate (denoted as MSN@Alg) was successfully synthesized by air-dynamic atomization and applied to the intracellular drug delivery systems (DDS) of liver cancer cells with sustained release and specific targeting properties. MSN@Alg microspheres have the advantages of MSN and alginate, where MSN provi...
Although, the drug delivery system (DDS) concept is not new, great progress has recently been made in the treatment of a variety of diseases. Targeting delivery of drugs to the diseased lesions is one of the most important aspects of DDS. To convey a sufficient dose of drug to the lesion, suitable carriers of drugs are needed. Nano and microparticle carriers have important potential application...
Objective(s): The aim of present research was to develop matrix-mini-tablets of lornoxicam filled in capsule for targeting early morning peak symptoms of rheumatoid arthritis. Materials and Methods:Matrix-mini-tablets of lornoxicam were prepared by direct compression method using microsomal enzyme dependent and pH-sensitive polymers which were further filled into an empty HPMC capsule. To asses...
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