The linear minimum mean-squared error (MMSE) detector for direct-sequence code-division multiple-access (DSCDMA) systems relies on the inverse of the covariance matrix of the received signal. In multiuser environments, when few samples are available for the covariance estimation, the matrix illconditioning may produce large performance degradation. In order to cope with this effect, we propose ...

The aim of the present study was to examine the effect of an intensified training phase followed by a tapering phase on the salivary immunoglobulin A concentration and on the upper respiratory tract infection (URTI) symptoms in young male basketball players. The session rating of perceived exertion method was used to quantify the internal training load, and the Wisconsin Upper Respiratory Sympt...

The design procedure of low-sensitivity active resistance-capacitance (RC) allpole filters, using impedance tapering, has already been published. The low-sensitivity filter sections already described in publication are class 4 (TT-SABB) Sallen and Key sections. In this paper class 3 (SAB) sections for low pole-Q realization are considered. Impedance tapering is applied on Lsections, which are ...

A procedure for the design of allpole filters with low sensitivity to component tolerance is presented. The filters are based on resistance–capacitance (RC) ladder structures combined with single operational amplifiers. It is shown that by the use of impedance tapering, in which L-sections of the RC ladder are successively impedance-scaled upwards, from the driving source to the amplifier input...

INTRODUCTION The current American College of Rheumatology and European League Against Rheumatism treatment recommendations advise tapering biological disease-modifying antirheumatic drug (bDMARD) therapy in patients with rheumatoid arthritis (RA) who achieve stable clinical remission while receiving bDMARDs. However, not all patients maintain remission or low disease activity after tapering or ...

Tapering is a common morphological modification to ensure the stability of civil structures, especially as more and high-rise buildings push skyline modern cities. However, aerodynamics, aeroelasticity, fluid-structure-interaction tapering remain far from been fully understood. Through wind tunnel tests, present work offers some notable observations on effects tapering, specifically considering...

Improvements in the control of inflammation in rheumatoid arthritis (RA) by conventional synthetic and biologic disease-modifying antirheumatic drugs (DMARDs) have led to a substantial change in the clinical outcomes of patients during the last 30 years. Current treatment can lead to sustained remission in some patients raising questions about the optimal management strategies in this subgroup ...

BACKGROUND Human leukocyte antigen (HLA)-identical living-related (LR) kidney transplant recipients often receive the standard regimen of immunosuppression. We wondered whether these patients should be exposed to the side effects of these drugs any longer. Safe tapering of immunosuppression should not result in rejection and high donor-directed T-cell responses. In the present study, we investi...

PURPOSE OF REVIEW Therapies for rheumatoid arthritis (RA) continue to expand rapidly. The purpose of this review is to discuss novel treatment options, including biosimilars, that are available, as well as to highlight promising agents in development. The purpose is also to discuss new emerging safety signals associated with these drugs and to discuss strategies in tapering therapy. RECENT FI...

We describe the design and operationalization of a blinded corticosteroid-tapering regimen for a randomized trial of tocilizumab in giant cell arteritis (GCA). To our knowledge, no clinical trial in any disease has ever employed a blinded corticosteroid-tapering regimen, but this was necessary to the design of our trial which is likely to be relevant to other investigations of steroid-sparing r...