The human cytomegalovirus (HCMV) protein US6 inhibits the transporter associated with antigen processing (TAP). Since TAP transports antigenic peptides into the endoplasmic reticulum for binding to major histocompatibility class I molecules, inhibition of the transporter by HCMV US6 impairs the presentation of viral antigens to cytotoxic T lymphocytes. HCMV US6 inhibits ATP binding by TAP, henc...

Dear Editors, We read with great interest a letter entitled ‘Cleansing of wounds by tap water? An evidence based systemic analysis’ by Huang et al. (1), commenting on the safety of tap water irrigation in wound cleansing. The tap water irrigation has been reported to reduce colonisation of wounds and infection rates significantly (2,3). It has also been found that the rate of infection and outc...

Newly assembled heavy chain-beta 2m heterodimers of class I histocompatibility molecules associate with the endoplasmic reticulum (ER) peptide transporter, TAP, and subsequently dissociate from TAP in parallel with their transport from the ER to the Golgi apparatus. It appears that TAP-associated class I molecules are waiting to bind appropriate peptides before they dissociate from TAP and leav...

The increasing prevalence of auctions as a method of conducting a variety of transactions has promoted interest in modelling bidding behaviours with simulated agent models. The majority of popular research has focused on double auctions, i.e. auctions with multiple buyers and sellers. In this paper we investigate agent models of sealed bid auctions, i.e. single seller auctions where each buyer ...

This Federal Judicial Center publication was undertaken in furtherance of the Center's statutory mission to conduct and stimulate research and development for the improvement of judicial administration. The views expressed are those of the authors and not necessarily those of the Federal Judicial Center.

1. Introduction. Recent empirical and anecdotal evidence suggests that different auction rules generate important differences in bidding behavior. Milgrom (1996) compares auctions for the sale of the radio spectrum held in the United States, New Zealand and Australia. The Australian and New Zealand auctions were characterized by wildly different prices for similar bandwidths. In the United Stat...

Tap has been proposed to play a role in general mRNA export and also functions in expression of RNA with retained introns that contain the MPMV CTE (constitutive transport element). Tap forms a functional heterodimer with NXT/p15. We have previously demonstrated that unspliced intron-containing CTE RNA is efficiently exported to the cytoplasm in mammalian cells. Here we show that Tap and NXT pr...

The mammalian protein TAP/p115 and its yeast homologue Uso1p have an essential role in membrane traffic (Nakajima et al., 1991; Waters et al., 1992; Sztul et al., 1993; Rabouille et al.; 1995). To inquire into the site and mechanism of TAP/p115 action, we aimed to localize it and to identify domains required for its function. We show that in interphase cells, TAP/p115 localizes predominantly to...