In the present study the effects of both CCK receptor agonists and antago­ nists on antinociception induced by morphine in the tail-flick test have been evalu­ ated. M orphine induced dose-dependent antinoci�eption in mice. The response of morphine was potentiated by sulfated cholecystokinin-8 (CCK-8S) but not by unsulfated cholecystokinin-8 (CCK-8U). The CCK receptor antagonists MK-329 and L-3...

BACKGROUND Cisplatin is an effective antineoplastic drug used extensively in the treatment of malignancies. It induces painful peripheral neuropathy at high doses. OBJECTIVES The aim of this study was to investigate the effect of carbamazepine (CBZ) on cisplatin-induced peripheral neuropathic pain by using the tail-flick test. MATERIALS AND METHODS The study was performed using male Wistar ...

The analgesic efficacy of cholinergic agonists and anticholinesterase agents has been widely recognized. The analgesic effect obtained by activating cholinergic mechanisms, however, seems to depend on the experimental pain model utilized for its evaluation. The antinociceptive effect of intraspinal neostigmine was examined in rats submitted concurrently to the tail flick and formalin tests. Neo...

OBJECTIVE Previous in vitro studies have shown that the degradation of [Leu5]enkephalin during incubation with cerebral membrane preparations is almost completely prevented by a mixture of three peptidase inhibitors such as amastatin, captopril, and phosphoramidon. The present in vivo study was performed to examine the antinociceptive effect of [Leu5]enkephalin administered intrathecally under ...

In this study, the analgesic, antipyretic and anti-inflammatory effects of the methanolic extract obtained from the leaves of Thunbergia coccinea Wall were investigated. Analgesic effect of MTC was evaluated by acetic acid –induced writhing, hot plate and tail flick method. Antipyretic activity of MTC was evaluated by yeast –induced hyperpyrexia in rats. The antiinflammatory activity was studie...

In the traditional medicine, Taxus baccata Linn. has been used as analgesic, anticonvulsant, and antiinflammatory remedy. In the present study, bark of plant was extracted with 95% ethanol and ether at room temperature and evaluate for their analgesic activity in mice using the tail-flick and acetic acid-induced writhing method. Ether extract exhibits potent analgesic activity in tail-flick tes...

Beta-endorphin (fS-EP) is a 31 amino acid polypeptide secreted by the pituitary, brain, and various other tissues. it has potent opiate-like activity, can produce analgesia, and may play a physiological role in adapting the immune system to stress by affecting Iymphocyte and complement binding activity. To investigate the effect of fS-EPon pain threshold, we analyzed cerebrospinal fluid (CSF) a...

OBJECTIVE S-Adenosylmethionine (SAMe) is a major methyl donor in the brain and is also an antidepressant with few reported side effects; however, SAMe is relatively expensive and unstable. Brain SAMe can be increased by giving methionine to rats, raising the possibility that methionine may be an antidepressant. We aimed to study whether SAMe and methionine, when given orally to rats, could rais...

A homozygous CGRP-/- mouse line was generated by the targeted disruption of exon 5 in the calcitonin/alphaCGRP gene using homologous recombination. The mutant mice lack alphaCGRP mRNA. Furthermore CGRP immunoreactivity almost completely disappears from the spinal cord and is not at all observed in spinal ganglia and muscle synapses. However, motor end plates were still detected by acetylcholine...