In this paper, we introduce sequence-based multiscale modeling for biomolecular data analysis. We employ spectral clustering method in our modeling and reveal the difference between sequence-based global scale clustering and local scale clustering. Essentially, two types of distances, i.e., Euclidean (or spatial) distance and genomic (or sequential) distance, can be used in data clustering. Clu...

To identify clinical and neuroimaging characteristics between posterior cortical atrophy (PCA) and typical amnestic Alzheimer's disease (tAD) patients at an early disease stage, 16 PCA and 13 age-matched tAD patients were enrolled. Compared with tAD patients, PCA patients showed higher mean recognition and recall test scores, and lower mean calculation, spatial attention, shape discrimination, ...

Three-dimensional genome structure plays an important role in gene regulation. Globally, chromosomes are organized into active and inactive compartments while, at the gene level, looping interactions connect promoters to regulatory elements. Topologically associating domains (TADs), typically several hundred kilobases in size, form an intermediate level of organization. Major questions include ...

Recent advancements in mobile technology allow global positioning system (GPS)-enabled cell phones to provide a variety of real-time location-based services. This study reports on the design, implementation and testing of such a service, the travel assistance device (TAD), that aids transit riders with special needs in using public transportation. TAD is a program that provides the rider with c...

The 3D organization of the genome changes concomitantly with expression changes during hematopoeisis and immune activation. However, studies of this phenomenon have focused either on topologically associated domains (TADs) or on lamina-associated domains (LADs) with few studies investigating how TADs and LADs affect one another. To address this we employed a Jurkat T-cell activation system. Lam...

BACKGROUND Posterior cortical atrophy (PCA) is a neurodegenerative condition predominantly associated with Alzheimer's disease (AD) pathology. Cross-sectional imaging studies have shown different atrophy patterns in PCA patients compared with typical amnestic Alzheimer's disease (tAD) patients, with greatest atrophy commonly found in posterior regions in the PCA group, whereas in the tAD group,...

Endovascular stent-graft implantation technique is a newly developed, effective and less invasive method in treating thoracic aortic dissection (TAD). Our study was designed to further verify the feasibility, the efficacy, and safety of this technique. We present a 4-year follow-up report of endovascular stent-graft treatment over 36 cases of acute TAD patients and 40 cases of chronic TAD patie...

A current question in the high-order organization of chromatin is whether topologically associating domains (TADs) are distinct from other hierarchical chromatin domains. However, due to the unclear TAD definition in tradition, the structural and functional uniqueness of TAD is not well studied. In this work, we refined TAD definition by further constraining TADs to the optimal separation on gl...

Early intensification of chemotherapy with high-dose cytarabine either in the postremission or remission induction phase has recently been shown to improve long-term relapse-free survival (RFS) in patients with acute myeloid leukemia (AML). Comparable results have been produced with the double induction strategy. The present trial evaluated the contribution of high-dose versus standard-dose cyt...

Patients with acute aortic dissection, the dominant condition in acute aortic syndromes, have a high mortality [1]. Within types of thoracic aortic dissection, the more extensive the TAD the worse the prognosis [2]. Thus, factors influencing the extent of the TAD are important considerations. The initial presentation of acute aortic dissection is severe chest pain and hypertension. The presence...