Eight children (aged between 8 1/2 and 15 1/2 years) with chronic renal failure receiving intermittent haemodialysis, and 2 children with renal transplants were studied. The response of TSH and prolactin (PRL), and basal T4 and T3 values was measured. Basal TSH was normal, and rose only slightly after TRH stimulation. Plasma T4 and T3 were below normal levels in 6 children. Mean basal PRL was r...

Serum thyrotropin (TSH) concentrations were measured serially in 14 heart-transplant recipients (group 1) and 21 patients undergoing coronary artery bypass surgery (group 2), all without thyroid disease, and randomly in 158 patients hospitalized for various other nonthyroidal illnesses, including 144 judged euthyroid (group 3), six with increased FT4 and (or) T3 (group 4), and eight classified ...

2-n-Butyl-3-(4'-diethylaminoethoxy-3',5'-diiodobenzoyl)-benzofurane (amiodarone), a drug used in arrythmias and angina pectoris, contains 75 mg of organic iodine/200 mg active substance. Four studies were performed to test its effect on thyroid hormone metabolism: (a) nine male subjects were treated with 400 mg of amiodarone for 28 days; (b) five male subjects received, for the same period of t...

We aimed to determine whether the lesion affected hypothalamus-anterior pituitary axis in 38 patients with cerebrovascular hemorrhage and infarct who did not have a thyroid disorder. For this purpose, we measured levels of serum thyroid hormones; T3 (triiodothyronin), T4 (tyroxin), FT3 (free T3), FT4 (free T4) and TSH (thyroid stimulating hormone) at 0 minute and TSH hormones were measured bu R...

SUMMARY In 28 school children with primary hypothyroidism due to iodine deficiency, 100 µg levothyroxine (L-T4} was administered for nine weeks and resulted in normalization of serum T4, T3, and TSH. Five months after withdrawal of L-T 4 , thyroid function was normal in the majority of subjects. Serum T4 was 8.6±2.3 µg/dl ; T3, 156±2.3 ng/dl; and TSH, 6.9± 12.7 µU/ml. Only one subjects showed ...

INTRODUCTION We evaluated relations between interleukins (IL) IL-6 and IL-10 and euthyroid sick syndrome (ESS) in patients with nonthyroidal illness (NTI). MATERIALS AND METHODS Sixty patients and 20 healthy volunteers were recruited. The patients had either chronic kidney disease (CKD), congestive heart failure (CHF), or acute myocardial infarction (MI), distributed equally in 3 subgroups. S...

In order to compare the effect of 3,5,3'-triiodothyroacetic acid (TRIAC) with those of triiodothyronine (T3) and thyroxine (T4), severely hypothyroid rats (n=56) were infused over 13 days with 1, 2 or 4 nmol/100 g body weight (BW) per day of T3 or 2, 4 or 8 nmol/100 g BW per day of T4 or TRIAC. The 8 nmol/100 g BW per day of T4 or TRIAC induced the same increase in resting metabolic rate, yet 4...

We present the first case of iatrogenic hypothyroidism as a result of compounded thyroid hormone (T4/T3) therapy. The thyroid replacement was changed from 175 µg levothyroxine (LT4) to 57/13.5 µg compounded T4/T3 daily in order to improve the T3 level, despite normal thyroid-stimulating hormone (TSH). This resulted in clinical manifestations of hypothyroidism and high TSH level (150 µIU/mL). Si...

a b c d Original Article The present study was conducted to estimate thyroid hormone levels i.e. T3, T4& TSH and to study the thyroid dysfunctions in patients with chronic renal failure. 30 male patients of aged between 40-70yrs with serum creatinine> 5.5mg/dl & urea > 55mg/dl and dipstick test positive for protein with symptoms of chronic renal failure are taken in the study.Serum levels of T3...

The response to an intravenous dose of 200 microng of thyrotrophin releasing hormone (TRH) has been studied by estimating, by radioimmunoassay, baseline levels followed by further estimations of thyroid stimulating hormone (TSH) 20 minutes after the injection and triiodothyronine (T3) three hours after the injection in 112 patients referred for routine thyroid assessment. Comparison of diagnost...