Introduction: Restless leg syndrome (RLS) is a sensory-motor disorder characterized by uncontrollable urges to move the legs, causing chronic sleep disturbances. Brain iron deficiency has been considered as an important contributing factor to RLS [1-2]. In this study, we applied voxel-based relaxometry (VBR) for in vivo iron measurement and voxel-based morphometry (VBM) for morphological study ...

BACKGROUND Determination of the relaxation time constants T1 and T2 with quantitative magnetic resonance imaging is increasingly used for both research and clinical practice. Recently, groups have been formed within the Society of Cardiovascular Magnetic Resonance to address issues with relaxometry. However, so far they have avoided specific recommendations on methodology due to lack of consens...

INTRODUCTION: The Achilles tendon is commonly involved in both degenerative and inflammatory tendinopathies. The short T2 of the normal tendon makes early changes difficult to assess with conventional MR sequences. Ultrashort echo time imaging (UTE) [1] can directly visualize the tendon signal allowing quantification, such as T1 relaxometry. T1 measurements may be useful for assessing Achilles ...

Heart failure (HF) patients show brain tissue loss or injury in autonomic, cognitive, and emotional regulatory areas (1, 2); the regions with tissue injury overlap sites of altered functional MRI signals to autonomic challenges (3, 4). Some structural injury appears on T2-relaxometry procedures, and could result from different pathological processes, including hypoxia/ischemia accompanying perf...

Background Magnetic resonance imaging (MRI) plays an essential role in molecular imaging by delivering the contrast agent into targeted cancer cells. The aim of this study was to evaluate the C595 monoclonal antibody-conjugated superparamagnetic iron oxide nanoparticles (SPIONs-C595) for the detection of breast cancer cell (MCF-7). Methods The conjugation of monoclonal antibody and nanopartic...

Rivastigmine has been shown to improve cognition in HIV+ patients with minor neurocognitive disorders; however, the mechanisms underlying such beneficial effect are currently unknown. To assess whether rivastigmine therapy is associated with decreased brain inflammation and damage, we performed T1/T2* relaxometry and magnetization transfer imaging in 17 aviremic HIV+ patients with minor neuroco...

Fiore Sardo (FS), a traditional Italian cheese, is present in the market as heterogeneous variety of products. The use heat-treated (HT) milk forbidden by official production protocol, but no analytical method able to detect heat application yet available. Here, combined magnetic resonance imaging (MRI) relaxometry and image analysis approach recognize FS made from raw presented. Artisanal chee...

Recently, clinical studies demonstrated that magnetic resonance relaxometry with determination of relaxation times T1 and T2⁎ may aid in staging and management of liver fibrosis in patients suffering from viral hepatitis and steatohepatitis. In the present study we investigated T1 and T2⁎ in different models of liver fibrosis to compare alternate pathophysiologies in their effects on relaxation...

PURPOSE To present a technique for simultaneous mapping of T1 , T2 , and relative spin density (M0 ) in human lung using inversion recovery ultra-fast steady-state free precession (IR-ufSSFP) imaging. METHODS Pulmonary relaxometry with IR-ufSSFP is based on an interleaved time series acquisition of 2D images acquired at 1.5T. The technique was tested in a phantom and in four healthy volunteer...