Genetic susceptibility to obstructive sleep apnea (OSA) has been a research focus in the scientific community in the past few years. In this study, we recruited 375 subjects to investigate whether functional polymorphisms in the promoter region of matrix metalloproteinase (MMP)-2 (-1306C/T) and MMP-9 (-1562C/T) increased susceptibility to OSA. Our study showed no significant association between...

BACKGROUND Previous studies have suggested that IL4, IL13, and IL4R are associated with serum IgE levels and allergies, and common variants of these genes may alter cancer risk. To clarify these associations, we conducted a meta-analysis to investigate the associations of IL4, IL13, and IL4R polymorphisms with gastrointestinal cancer risk. METHODS We used 27 eligible case-control studies desc...

BACKGROUND A C825T polymorphism was recently identified in the gene encoding the beta3 subunit of heterotrimeric G-proteins (GNB3). The T-allele is significantly associated with essential hypertension and obesity. In order to further explore a possible pathogenetic link between the T-allele and impaired glucose tolerance we studied metabolic and haemodynamic responses to oral glucose loading in...

INTRODUCTION This study is to elucidate the relationship between a 936C/T mutation at the 3'-untranslated region of the human vascular endothelial growth factor (VEGF) gene and diabetic peripheral neuropathy (DPN). MATERIAL AND METHODS All subjects recruited in this study were divided into DM (diabetes without neuropathy, retinopathy or nephropathy), DPN (diabetes with peripheral neuropathy o...

ESR1 has been listed in the Human Obesity Gene Map as candidate gene associated with obesity. Thus, in this study, we investigated the effect of the ESR1 rs1884051 polymorphism on obesity-related variables, together with their modulations by dietary intake in Korean men. The obesity-related variables and dietary intake of 3,039 Korean men aged 40-59 years from KoGES database were analyzed. Body...

background: survival of the semi-allograft fetus during pregnancy opens a new area for the immunological based causes of recurrent spontaneous abortion (rsa). cytotoxic t lymphocyte-associated antigen 4 (ctla4) is a negative regulator of the t-cell activation, which may modulate peripheral self-tolerance of the allogeneic fetus. the present study aimed to investigate the +49 a/g ctla4 genetic p...

promoter polymorphism of cytokine genes may lead to inter-individual differences in cytokine levels, therefore, polymorphisms may associate with susceptibility to infectious diseases. in this study, we investigated a possible association between interleukin-10 (il-10) -1082a⁄g (rs1800896) and interferon (ifn)-gamma +874t/a (rs2430561) promoter polymorphisms and tuberculosis (tb) in the azeri po...

Sustained attention is modulated by the neurotransmitter noradrenaline. The balance of dopamine and noradrenaline in the cortex is controlled by the DBH gene. The principal variant in this gene is a C/T change at position -1021, and the T allele at this locus is hypothesised to result in a slower rate of dopamine to noradrenaline conversion than the C allele. Two hundred participants who were g...

  Background: Both genetic and environmental factors are important in pathogenesis of diabetes. Non HLA (Human Leukocyte Antigen) genes such as INS-VNTR and CTLA-4 in addition of HLA genes have influence on genetic susceptibility for diabetes mellitus. In this study the association of +49 A/G CTLA-4 and -23 A/T INS-VNTR polymorphisms with diabetes and their association with islet auto...

background: atp-binding cassette transporter a1 (abca1) is a membrane integral protein which plays a vital role in high density lipoprotein (hdl) metabolism and exerts a protective effect against hypoalphalipoproteinemia (ha) by mediation of rate-limiting step in hdl biogenesis. in addition, this protein possesses anti-inflammatory effects by inhibiting the production of some inflammatory cytok...